Fig.4
From: Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment
Impaired cognitive function in young exercising Bp5 tg + mice. a Escape latency of 3-month-old WTSed and WTRun mice. b Escape latency of 3-month-old Bp5 tg + Sed and Bp5 tg + Run mice. c, d, e, f Representative images of the path travelled during the probe trial, illustrating the preference of 3-month-old WTRun mice for the platform area compared to 3-month-old WTSed, Bp5 tg + Sed and Bp5 tg + Run mice. g Time in the platform area of 3-month-old WTSed, WTRun, Bp5 tg + Sed and Bp5 tg + Run mice. h Travelled distance in the platform area of 3-month-old WTSed, WTRun, Bp5 tg + Sed and Bp5 tg + Run mice. i Global route of 3-month-old WTSed, WTRun, Bp5 tg + Sed and Bp5 tg + Run mice. j Velocity of 3-month-old WTSed, WTRun, Bp5 tg + Sed and Bp5 tg + Run mice. k Escape latency of 18-month-old WTSed and WTRun mice. l Escape latency of 18-month-old Bp5 tg + Sed and Bp5 tg + Run mice. m, n, o, p Representative images of the path travelled during the probe trial showing no preference of 18-month-old WTRun mice for the platform area compared to 18-month-old WTSed, Bp5 tg + Sed and Bp5 tg + Run mice. q Time in the platform area of 18-month-old WTSed, WTRun, Bp5 tg + Sed and Bp5 tg + Run mice. r Travelled distance in the platform area of 18-month-old WTSed, WTRun, Bp5 tg + Sed and Bp5 tg + Run mice. s Global route of 18-month-old WTSed, WTRun, Bp5 tg + Sed and Bp5 tg + Run mice. t Velocity of 18-month-old WTSed, WTRun, Bp5 tg + Sed and Bp5 tg + Run mice. Data represents mean ± SD, a, b, k, l = Two-way ANOVA, Bonferroni's multiple comparison tests; g, h, i, j, q, r, s, t = One-way ANOVA, Tukey’s multiple comparison tests; *p < 0.05, **p < 0.01, ***p < 0.001; n = number of mice. Blue highlighted area = target quadrant