Fig. 4
From: Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ
Human Aβ1-42 reduces NMDAR current in left, but not right, CA3-CA1 synapses in wild-type mice. a Sample traces from currents recorded in hippocampal CA1 neurons after optogenetic activation of axons originating in left or right CA3. Currents in control conditions and after Aβ incubation are presented. b Cumulative distribution plot showing synaptic NMDAR charge transfer (NMDAQ/AMPAmax), N/A ratio, and weighted NMDAR current decay time constant (τw) in synapses activated by inputs from left CA3 or right CA3, showing a selective inhibition (shift to the left) by hAβ1-42 in synapses with input from the left CA3 only. Each point represents the average value per cell. Statistical comparisons are presented in Table 1