Fig. 3

Non-vascular localisation of MPO in human Alzheimer’s disease. Tissue microarrays of human middle temporal gyrus were stained for MPO with pTau, amyloid-β, or CD66B. a Representative images of non-vascular MPO localisation associated with pTau tangles, amyloid-β plaques, and infiltrating CD66B-positive neutrophils. Scale = 25 μm. Quantification of the amount of b extravascular MPO, c MPO-positive plaques, and d MPO-positive tangles. Values represent results of an two-tailed Student’s T-test. e Percentage of extravascular MPO associated with plaques and tangles. Correlation of total MPO load in tissue with the load of f plaques and g tangles. Values represent results of a Pearson’s correlation test