Fig. 6

Quantification of the colocalization of ABCA7-EmGFP and the ER. The Pearson’s correlation coefficient between the ABCA7-EmGFP channel and the Calreticulin channel was measured with ImageJ on a minimum of 30 cells per genotype. Data are represented as median values, with lower and upper quartiles and the value ranges (whiskers). (*p < 0.05; **p < 0.01; ***p < 0.001 after Games-Howell correction). Presence of neurofibrillary tangles (arrow) and dystrophic neurites (asterisk) in the hippocampus (A). Presence of diffuse plaques and capillary amyloid angiopathy (arrow) in the hippocampus (B). Scale bars represent 50 µm. Details on the protocol of the neuropathologic assessment can be found in the Additional file 1: Materials and Method section