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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies

Fig. 2

Subregional morphological alterations of microglia in the hippocampus of AD patients. Using MIC-MAC 2.0, we have extracted 16 geometrical features per cell of 32,447 individual microglia collected in CA1, CA3 and DG/CA4 subfields from AD, DLB and age-matched CTLs. None of the analyzed microglia morphological features was significantly changed in the DLB samples but follow a trend similar to the AD condition. All the following reported changes are observed in AD vs CTL samples. a Compactness is significantly increased in all three hippocampal subregions, b and volume over number of edges is significantly increased in CA1 and DG/CA4. (c) Node density significantly decreases in CA1 and DG/CA4, as does ending nodes density in CA3 (d). Two features, namely average node degree and s-metric present significant intra-condition regional changes (e, f). Wilcoxon–Mann–Whitney U-test P values are indicated in the graphs: *P < 0.05 and **P < 0.01. Scaled prototypic morphologies with highest and lowest value for the selected feature have been added on the left side. Scale bar = 20 µm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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