Fig. 9
From: TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss
A diagram summarizing cerebellar pathologies in Tmem106b−/− mice with age. At 2 months of age, Tmem106b−/− young mice exhibit lysosome and myelination defects, and a significant loss of synapses between Purkinje and deep cerebellar nuclei neurons. Purkinje cell axonal demyelination and swelling are observed at 5 months of age. Significant loss of Purkinje neurons specifically in the anterior lobe of the cerebellum are observed in 16-month of age, accompanied by increased microglia and astrocyte activation, and the accumulation of ubiquitinated proteins, p62, and TDP-43