Fig. 7
From: Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization
Inhibition of physiological extrasynaptic NR2B exacerbates tau pathology Immunocytochemistry of aggregated endogenous mouse tau in ADPHF treated hippocampal neurons. Neurons were treated with a PBS, b Memantine, c ADPHF for 14 days in vitro (DIV), d ADPHF 14DIV and Memantine, e ADPHF 14DIV, Memantine, and TBB; scale bar = 50 µm. f Quantification of mouse tau normalized to DAPI. h Quantification of synaptic NR2B normalized to DAPI. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, one-way ANOVA followed by Tukey post hoc test. n = 6/group