Fig. 5

Assessment of behavioral and motor disorders in mice with the C215Y mutation. A–C C215Y/ + , and even more so the homozygous C215Y/C215Y mice, display hyperlocomotion in the open field test. Data are shown as the distance moved by a mouse (A) and the velocity of the mouse (B) for the two mutant genotypes and their wt littermates, measured in the 0–10 min, 10–20 min, 20–30 min intervals of the experiment, and the overall 0–30 min of the experiment. Representative trail plots are shown in (C). D C215Y/ + mice outperformed the wt littermates in the swimming test. E In the rotarod test, C215Y/ + mice outperformed their wt littermates. Quantification of the time to fall parameter over the four days of the experiments is shown. F Group mean of the time in open arms in the elevated plus maze for the three genotypes. In all panels data is given as mean ± sem. *p < 0.05, **p < 0.01, ***p < 0.001, + / + vs. C215Y/C215Y, #p < 0.05, ##p < 0.01, ###p < 0.001 + / + vs. C215Y/ + , &p < 0.05, &&p < 0.01, &&&p < 0.001 C215Y/ + vs. C215Y/C215Y as determined by two-way ANOVA with Dunnett’s multiple comparison test (A, B, D, E) and t-test (F); n = 8 (wt), 17 (C215Y/ +) and 6 (C215Y/C215Y) mice