Neurodegenerative brain changes are associated with area deprivation in the United Kingdom: findings from the Brains for Dementia Research study

Table 3 Association between area deprivation and grading of Alzheimer’s disease neuropathologic changes

Adjusted Odds	Thal Amyloid Phase		Braak Tangle Stage		CERAD Plaque Score
Adjusted Odds	Odds Ratios	CI	Odds Ratios	CI	Odds Ratios	CI
IMD Stratum 2 vs 1	1.26	0.77 – 2.06	1.23	0.79 – 1.90	1.26	0.77 – 2.05
IMD Stratum 3 vs 1	1.18	0.70 – 2.00	1.06	0.66 – 1.70	1.05	0.62 – 1.78
IMD Stratum 4 vs 1	0.76	0.42 – 1.39	0.81	0.45 – 1.46	0.72	0.38 – 1.38
IMD Stratum 5 vs 1	1.37	0.71 – 2.62	1.81	1.01 – 3.23	2.09	1.09 – 3.98
Covariates:
Age at Death	1.01	0.99 – 1.03	0.97	0.95 – 0.99	0.99	0.97 – 1.01
APOE ε4 Carrier	3.78	2.57 – 5.56	3.38	2.38 – 4.80	3.19	2.17 – 4.67
Diabetes	0.71	0.39 – 1.29	0.83	0.48 – 1.43	0.86	0.47 – 1.56
Hypertension	0.84	0.58 – 1.21	0.70	0.50 – 0.98	0.69	0.48 – 1.00
Male Sex	0.98	0.67 – 1.44	0.81	0.57 – 1.15	0.84	0.57 – 1.24
Smoker	0.98	0.66 – 1.44	1.20	0.84 – 1.70	0.96	0.65 – 1.41
Alcohol Misuse	0.95	0.50 – 1.82	1.17	0.65 – 2.08	1.66	0.83 – 3.31

ISSN: 2051-5960