Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome

Table 11 Correlations in DS cohort

Structure	Correlation with neuron number of:
	Structure volume	NFT number	NFT%
Entorhinal cortex—all layers	0.89***	−0.09	− 0.74***
Entorhinal cortex —islands	0.93***	0.25	− 0.89***
CA1	0.92***	− 0.01	− 0.76***
CA2	0.79***	− 0.44^*	− 0.66***
CA3	0.80***	− 0.24	− 0.61***
CA4	0.41*	− 0.29	− 0.62***
Subiculum	0.92***	− 0.17	− 0.53***
Amygdala	0.60***	0.04	− 0.46***
Thalamus	0.53^***	− 0.31	− 0.37
Substantia nigra	0.85***	− 0.06	− 0.41*
Magnocellular basal complex	0.85***	− 0.16	− 0.50**
CN	0.87***	− 0.20	− 0.38*
DN	0.22	0.28	− 0.15

ISSN: 2051-5960