Table 1 Clinical and neuropathological characteristics of DS subjects
# | Case # | Sex | Age (y) | Cause of death | Intellectual (IQ) deficit | Epilepsy | APOE allele | Dementia | Brain weight (g) | BraakStage: NFTs | Thal Phase: Aβ plaques |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 207–93 | M | 26 | No signs | 1,160 | I | 0 | ||||
2 | 292–00 | M | 28 | Gastrointest. hemorrhage | No signs | 1,320 | I | 5 | |||
3 | 37–98 | M | 41 | Severe, 28 | Mild | 1,130 | II | 5 | |||
4 | M16-03 | F | 41 | Peritonitis | Severe, 20 | No signs | 926 | IV | 5 | ||
5 | 256–00 | F | 43 | Pneumonia | Profound, 17 | 3/4 | No signs | 990 | V | 5 | |
6 | 257–00 | M | 48 | Pneumonia | Profound, 12 | No signs | 940 | IV | 5 | ||
7 | M9-04 | M | 48 | Pneumonia | Severe, 27 | + | 4/4 | Mild | 920 | VI | 5 |
8 | 24–98 | M | 49 | Mild, 50 | Mild | 1,100 | III | 5 | |||
9 | 1–98 | M | 51 | Moderate, 41 | Mod/ severe | 840 | VI | 5 | |||
10 | 511–02 | M | 51 | Pneumonia | Mod/ severe | 954 | VI | 5 | |||
11 | 512–02 | M | 52 | Cardiac infarct | Mod/ severe | 1,194 | VI | 5 | |||
12 | 482–97 | F | 54 | Pneumonia | Profound, 19 | + | 3/3 | 900 | VI | 5 | |
13 | 181–00 | M | 54 | Pneumonia | Moderate, 42 | Mild | 1,060 | VI | 5 | ||
14 | 55–03 | M | 54 | Sepsis | 3/3 | 774 | VI | 5 | |||
15 | M18-03 | F | 56 | SUDEP | Mild, 50 | + | Mild | 656 | VI | 5 | |
16 | M1-05 | F | 56 | Asp. pneumonia | Moderate, 43 | + | Severe | 822 | VI | 5 | |
17 | M2-09 | M | 56 | Asp. pneumonia | Mild, 58 | + | 3/3 | Mod/ severe | 762 | VI | 5 |
18 | M2-06 | M | 56 | Cardiac infarct | 4/4 | 1,114 | VI | 5 | |||
19 | M10-04 | F | 57 | Pneumonia | Moderate, 42 | + | 3/3 | Mod/ severe | 960 | VI | 5 |
20 | M3-05 | F | 57 | Cardiac failure | 3/4 | 696 | VI | 5 | |||
21 | M1-06 | M | 57 | 3/3 | 1,000 | VI | 5 | ||||
22 | 552–97 | F | 57 | Profound, 15 | 3/3 | Mod/ severe | 790 | VI | 5 | ||
23 | 615–97 | F | 59 | Cardiac failure | Profound, 18 | 4/3 | Severe | 740 | VI | 5 | |
24 | 649–97 | M | 59 | Profound, 5 | Severe | 1,060 | VI | 5 | |||
25 | M11-04 | M | 59 | Pneumonia | Moderate, 43 | 3/4 | Severe | 1,028 | VI | 5 | |
26 | M2-05 | M | 61 | Pneumonia | Severe, 27 | Severe | 1,208 | VI | 5 | ||
27 | M3-06 | F | 61 | Subdural cerebellar hemorrhage | 2/3 | Severe | 1,102 | VI | 5 | ||
28 | 37–99 | M | 63 | Pneumonia | Severe, 20 | + | Severe | 700 | VI | 5 | |
29 | 650–97 | F | 65 | Severe, 26 | 4/4 | Severe | 830 | VI | 5 | ||
30 | 258–00 | M | 65 | Pneumonia | 3/3 | Mod/ severe | 900 | VI | 5 | ||
31 | 256–99 | M | 67 | Severe | 700 | VI | 5 | ||||
32 | M18-07 | M | 71 | Multiple white matter infarcts | Severe, 26 | + | 3/3 | Mod/ severe | 960 | VI | 5 |
33 | 483–97 | F | 72 | 1,100 | VI | 5 |