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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome

Fig. 1

Braak staging of neurofibrillary degeneration and Thal staging of β-amyloidosis. Examination of serial equidistant coronal sections stained with mAb Tau-1 detecting NFTs revealed that topographic expansion of neurofibrillary degeneration in subjects with DS results in progression from Braak stage I in 25- and 26-year-old subjects to stage VI in all subjects 51 years of age and older. The pattern of amyloid plaque distribution corresponds to Thal phase 5 in all subjects 28 years of age and older. Observed pattern reflects completion of topographic expansion at the beginning of fourth decade

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Acta Neuropathologica Communications

ISSN: 2051-5960

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