Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome

Table 1 Aβ and tau scoring criteria by number of pathological markers per mm²

X	Aβ	Tau
0	< 1 plaque/mm²	< 1 mature NFT/mm²
1	< 1 dense-cored plaque but ≥ 2 total plaques	1–5 NFTs
2	≥ 1 dense-cored but < 2 neuritic plaques	5–12 NFTs
3	≥ 5 dense-cored and 2–15 neuritic plaques	12–25 NFTs
4	≥ 15 neuritic plaques	≥ 25 mature NFTs

ISSN: 2051-5960