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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds

Fig. 2

Staining for pS129 α-synuclein (Wako pSyn#64) following oral administration of assembled A53T α-synuclein to M83± mice. A Two months after oral administration. SOL, solitary nucleus; DMNX, dorsal motor nucleus of the vagus nerve; IML, intermediolateral nucleus of the thoracic spinal cord. B Additional staining three and four months after oral administration. AP, area postrema; RET, reticular formation (gigantocellular nucleus, Gi); RN, raphe nucleus; XII, hypoglossal nucleus; PAG, periaqueductal grey; MLF, medial longitudinal fasciculus. C Additional staining five months after oral administration until endpoint. BNST, bed nucleus of the stria terminalis; HYP, hypothalamus (anterior nucleus, AHN); SPLH, lateral horn of the spinal cord; THAL, thalamus (reticular nucleus, TRN); AMYG, amygdala; SPLF, spinal lateral funiculus, SNPC, substantia nigra pars compacta; SNPR, substantia nigra pars reticulata; VTA, ventral tegmental area. Scale bars, 50 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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