Fig. 5From: RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulationEffects of mutations in the Ca2+ binding site on the gating of RyR1 channels. Representative single channel traces of WT RyR1 (A), E3893A (B), E3893D (C), E3967A (D), and E3967D (E), under 150 nM Ca2+, 10 µM Ca2+, or 10 mM Ca2+. F, Po versus Ca2+ concentration curve. Data are presented as mean ± S.E.M from 6 single channels for each groupBack to article page