Fig. 3
From: RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation
Effects of ATP binding site mutations on the gating of RyR1 channels. A Representative single channel traces of WT RyR1 (top), T4979F (middle), and K4211S/K4214S/R4215S (bottom) under 10 µM Ca2+ only (left) or 10 µM Ca2+ and 1 mM ATP (right). B Po, C To, and D Tc of single WT RyR1, T4979F, and K4211S/K4214S/R4215S mutants. Data are presented as mean ± S.E.M from 6 single channels for each group. *P < 0.05