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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: A novel SMARCA2-CREM fusion: expanding the molecular spectrum of intracranial mesenchymal tumors beyond the FET genes

Fig. 2

Genetic features. A RNAseq analysis highlights a fusion between SMARCA2 (pink) and CREM (blue) genes, respectively located on chr9p24.3 and chr10p11.21. As the breakpoints are intra exonic (in exon 4 for SMARCA2, and exon 9 for CREM), the fusion point can easily been detected by split and span reads encompassing the rearrangement with a good coverage. B Chimeric protein between SMARCA2 and CREM with retained protein domain of SMARCA2 detected by the immunohistochemical antibody. C Immunopositivity for SMARCA2 in the current tumor (magnification, 400x)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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