Table 3 Gene Ontology (GO) and analysis of Biological Processes (BP) in which specific genes are involved
From: Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression
Up-regulated genes in alive × dead | ||||
|---|---|---|---|---|
Functional category | Genes in list | Total genes | FDR | Genes |
Nervous system development | 22 | 2474 | 0.004805005 | ARX HAPLN2 SLITRK5 VCX3A VCX ZNF365 NRTN TFAP2B NGFR MYB GFAP LRRTM2 LHFPL4 DPYSL5 FABP7 FOXG1 VIT MPZ CA10 KCNQ2 ACHE HPCAL4 |
Central nervous system development | 12 | 1054 | 0.029644095 | HAPLN2 VCX3A VCX ARX GFAP ZNF365 FABP7 SLITRK5 FOXG1 VIT CA10 HPCAL4 |
Regulation of hormone levels | 9 | 583 | 0.029644095 | ACHE PCSK1N MYB VGF RDH5 BCO1 TFAP2B KCNJ11 MYRIP |
Down-regulated genes in alive × dead | ||||
|---|---|---|---|---|
Functional category | Genes in list | Total genes | FDR | Genes |
Cornification | 17 | 125 | 8.55E−15 | TMEM79 TGM1 KRT37 PI3 KRT17 KLK14 TCHH KRT82 SPRR2D KLK13 KRT80 JUP KLK12 KRT25 SPINK9 KRT81 SPRR2A |
Epithelium development | 42 | 1386 | 9.40E−15 | KLK14 SPRR2D OVOL1 NRARP SPRR2A HGF TGM1 BMP4 FGF7 AJAP1 WNT11 CNFN DLX5 ALOX12 SDC1 ID3 TBX4 KRT17 GREB1L ADAMTSL4 RSPO3 TCHH ELF3 TMEM79 HEYL GREM1 ROR2 SIX2 SOX11 KRT25 SULT2B1 TBX1 RHCG KRT37 PI3 KRT82 KLK13 KRT80 JUP KLK12 SPINK9 KRT81 |
Epithelial cell differentiation | 33 | 831 | 1.67E−14 | SPRR2D OVOL1 SPRR2A TGM1 BMP4 AJAP1 CNFN DLX5 SDC1 ID3 KRT17 ADAMTSL4 TCHH ELF3 TMEM79 GREM1 SIX2 SOX11 WNT11 SULT2B1 TBX1 RHCG KRT37 PI3 KLK14 KRT82 KLK13 KRT80 JUP KLK12 KRT25 SPINK9 KRT81 |
Tissue development | 51 | 2168 | 2.40E−14 | KLK14 SPRR2D OVOL1 NRARP SPRR2A HGF TGM1 ZBTB16 BMP4 FGF7 AJAP1 PITX1 WNT11 SMPD3 CNFN DLX5 ALOX12 SDC1 ID3 TBX4 KRT17 GREB1L ADAMTSL4 RSPO3 FGF18 TCHH PKDCC ELF3 TMEM79 HEYL GREM1 ROR2 ADRB2 SIX2 SOX11 KRT25 COL8A1 SULT2B1 SIK1 ACTG2 TBX1 RHCG KRT37 PI3 KRT82 KLK13 KRT80 JUP KLK12 SPINK9 KRT81 |
Skin development | 23 | 464 | 1.11E−11 | SPRR2D SPRR2A TGM1 CNFN ALOX12 KRT17 FGF7 TCHH TMEM79 OVOL1 JUP ALOX12B KRT25 CLDN4 KRT37 PI3 KLK14 KRT82 KLK13 KRT80 KLK12 SPINK9 KRT81 |
Keratinization | 18 | 268 | 4.20E−11 | TGM1 CNFN KRT17 TCHH SPRR2D TMEM79 SPRR2A KRT37 PI3 KLK14 KRT82 KLK13 KRT80 JUP KLK12 KRT25 SPINK9 KRT81 |
Animal organ development | 62 | 3779 | 4.72E−11 | SPRR2D HEYL SIX2 SPRR2A HGF TGM1 ZBTB16 BMP4 FGF7 GREB1L AJAP1 MAFB MYOC USP2 PITX1 NOTCH3 WNT11 ANGPT2 SLC8A3 SMPD3 CNFN DLX5 ALOX12 MDFI SDC1 ID3 TBX4 KRT17 CYP19A1 COL8A1 RSPO3 FGF18 TCHH PKDCC ELF3 TMEM79 ZC3H12A AVPR1A GREM1 ROR2 ADRB2 OVOL1 JUP SOX11 ALOX12B CCBE1 NRARP PAPSS2 KRT25 TBX1 CLDN4 SIK1 ACTG2 KRT37 PI3 KLK14 KRT82 KLK13 KRT80 KLK12 SPINK9 KRT81 |
Epidermal cell differentiation | 21 | 410 | 5.29E−11 | SPRR2D OVOL1 SPRR2A TGM1 BMP4 CNFN KRT17 TCHH TMEM79 SULT2B1 KRT37 PI3 KLK14 KRT82 KLK13 KRT80 JUP KLK12 KRT25 SPINK9 KRT81 |
Epidermis development | 23 | 521 | 6.96E−11 | KLK14 SPRR2D OVOL1 SPRR2A TGM1 BMP4 CNFN KRT17 FGF7 TCHH TMEM79 KRT25 SULT2B1 ELF3 KRT37 PI3 KRT82 KLK13 KRT80 JUP KLK12 SPINK9 KRT81 |
Keratinocyte differentiation | 18 | 346 | 1.87E−09 | SPRR2D SPRR2A TGM1 CNFN KRT17 TCHH TMEM79 KRT37 PI3 KLK14 KRT82 KLK13 KRT80 JUP KLK12 KRT25 SPINK9 KRT81 |
Ossification | 18 | 396 | 1.56E−08 | MYOC ZBTB16 BMP4 TWIST2 WNT11 SMPD3 DLX5 ID3 GDPD2 FGF18 PKDCC ROR2 ADRB2 SIX2 SOX11 GREM1 CREB3L1 HGF |
Cellular developmental process | 64 | 4671 | 3.21E−08 | WNT11 DLX5 ID3 BMP4 NGF SPRR2D ELF3 HEYL OVOL1 RHOD SOX11 SPRR2A MYOC TGM1 ZC3H12A GREM1 AJAP1 MAFB TWIST2 HGF PITX1 NOTCH3 ANGPT2 SLC8A3 SMPD3 CNFN ZBTB16 MDFI SDC1 KRT17 CHN1 GDPD2 CATSPERB CD36 SIK1 ADAMTSL4 FGF18 TCHH FBLIM1 PKDCC TMEM79 AVPR1A ROR2 ADRB2 SIX2 GTSF1 NRARP COL8A1 SULT2B1 CREB3L1 S100A9 TBX1 RHCG KRT37 PI3 KLK14 KRT82 KLK13 KRT80 JUP KLK12 KRT25 SPINK9 KRT81 |
Cell differentiation | 62 | 4459 | 3.79E−08 | WNT11 DLX5 ID3 BMP4 NGF SPRR2D ELF3 HEYL OVOL1 SOX11 SPRR2A MYOC TGM1 ZC3H12A AJAP1 MAFB TWIST2 HGF PITX1 NOTCH3 ANGPT2 SLC8A3 SMPD3 CNFN ZBTB16 MDFI SDC1 KRT17 CHN1 GDPD2 CATSPERB CD36 SIK1 ADAMTSL4 FGF18 TCHH PKDCC TMEM79 AVPR1A GREM1 ROR2 ADRB2 SIX2 GTSF1 NRARP COL8A1 SULT2B1 CREB3L1 S100A9 TBX1 RHCG KRT37 PI3 KLK14 KRT82 KLK13 KRT80 JUP KLK12 KRT25 SPINK9 KRT81 |
Anatomical structure morphogenesis | 46 | 2785 | 1.00E−07 | PITX1 DLX5 KLK14 NGF HEYL RHOD NRARP HGF MYOC BMP4 IL1RN FGF7 ZC3H12A GREM1 AJAP1 NOTCH3 WNT11 ANGPT2 SMPD3 ALOX12 ZBTB16 MDFI SDC1 ID3 TBX4 KRT17 CHN1 CD36 GREB1L COL8A1 RSPO3 FGF18 FBLIM1 PKDCC ELF3 TMEM79 ROR2 SIX2 SOX11 CCBE1 MAFB KRT25 CREB3L1 JUP TBX1 ACTG2 |
Tissue morphogenesis | 21 | 719 | 8.87E−07 | KLK14 NRARP HGF BMP4 AJAP1 WNT11 ALOX12 TBX4 KRT17 FGF7 GREB1L RSPO3 TMEM79 HEYL GREM1 ROR2 SIX2 SOX11 KRT25 ACTG2 TBX1 |
Regulation of cartilage development | 8 | 68 | 1.39E−06 | ZBTB16 BMP4 SMPD3 FGF18 PKDCC SIX2 GREM1 WNT11 |
Tube development | 25 | 1062 | 1.93E−06 | NRARP BMP4 FGF7 ZC3H12A HGF NOTCH3 WNT11 ANGPT2 SMPD3 ALOX12 SDC1 TBX4 GREB1L COL8A1 RSPO3 FGF18 PKDCC HEYL GREM1 SIX2 SOX11 CCBE1 CREB3L1 JUP TBX1 |
Morphogenesis of an epithelium | 18 | 581 | 3.91E−06 | KLK14 NRARP HGF BMP4 AJAP1 WNT11 ALOX12 TBX4 KRT17 FGF7 GREB1L RSPO3 TMEM79 GREM1 ROR2 SIX2 SOX11 KRT25 |
Urogenital system development | 14 | 346 | 4.57E−06 | SIX2 BMP4 GREB1L NOTCH3 WNT11 ANGPT2 ZBTB16 SDC1 ID3 CYP19A1 HEYL GREM1 OVOL1 SOX11 |
Kidney development | 13 | 291 | 4.57E−06 | SIX2 BMP4 GREB1L NOTCH3 WNT11 ANGPT2 ZBTB16 SDC1 ID3 HEYL GREM1 OVOL1 SOX11 |
Regulation of anatomical structure morphogenesis | 25 | 1125 | 4.57E−06 | NGF RHOD HGF MYOC BMP4 IL1RN FGF7 ZC3H12A AJAP1 WNT11 ANGPT2 ALOX12 CHN1 CD36 FBLIM1 GREM1 ROR2 SIX2 CCBE1 NRARP FGF18 CREB3L1 JUP TBX1 RSPO3 |
Regulation of ossification | 11 | 193 | 4.57E−06 | ZBTB16 BMP4 TWIST2 ID3 GDPD2 PKDCC ADRB2 SIX2 SOX11 GREM1 HGF |
Skeletal system development | 17 | 541 | 6.10E−06 | ZBTB16 BMP4 MYOC PITX1 SMPD3 DLX5 MDFI FGF18 PKDCC ROR2 SIX2 SOX11 PAPSS2 WNT11 TBX4 GREM1 TBX1 |
Renal system development | 13 | 307 | 7.35E−06 | SIX2 BMP4 GREB1L NOTCH3 WNT11 ANGPT2 ZBTB16 SDC1 ID3 HEYL GREM1 OVOL1 SOX11 |
Animal organ morphogenesis | 24 | 1099 | 1.06E−05 | HEYL HGF BMP4 FGF7 AJAP1 WNT11 SMPD3 DLX5 MDFI SDC1 ID3 GREB1L COL8A1 FGF18 ELF3 GREM1 ROR2 SIX2 SOX11 MAFB TBX4 TBX1 ACTG2 RSPO3 |
Osteoblast differentiation | 11 | 218 | 1.18E−05 | MYOC BMP4 TWIST2 WNT11 DLX5 ID3 GDPD2 GREM1 SOX11 CREB3L1 HGF |
Regulation of developmental process | 41 | 2763 | 1.21E−05 | ID3 NGF HEYL RHOD HGF MYOC ZBTB16 BMP4 IL1RN FGF7 ZC3H12A AJAP1 MAFB TWIST2 NOTCH3 WNT11 ANGPT2 SMPD3 ALOX12 KRT17 CHN1 GDPD2 CD36 FGF18 FBLIM1 PKDCC TMEM79 GREM1 ROR2 ADRB2 SIX2 SOX11 CCBE1 NRARP CREB3L1 JUP SULT2B1 SIK1 S100A9 TBX1 RSPO3 |
Anatomical structure formation involved in morphogenesis | 24 | 1164 | 2.67E−05 | DLX5 NRARP BMP4 ZC3H12A HGF NOTCH3 WNT11 ANGPT2 SMPD3 TBX4 CD36 COL8A1 RSPO3 FGF18 HEYL GREM1 ROR2 SIX2 SOX11 CCBE1 MAFB CREB3L1 JUP TBX1 |
Skeletal system morphogenesis | 11 | 245 | 3.39E−05 | SMPD3 DLX5 MDFI BMP4 FGF18 ROR2 SIX2 SOX11 TBX4 GREM1 TBX1 |
Regulation of chondrocyte differentiation | 6 | 49 | 3.91E−05 | BMP4 FGF18 PKDCC SIX2 ZBTB16 GREM1 |
Appendage morphogenesis | 9 | 155 | 3.91E−05 | PITX1 DLX5 ZBTB16 TBX4 BMP4 PKDCC GREM1 ROR2 SOX11 |
Limb morphogenesis | 9 | 155 | 3.91E−05 | PITX1 DLX5 ZBTB16 TBX4 BMP4 PKDCC GREM1 ROR2 SOX11 |
Tube morphogenesis | 20 | 860 | 3.91E−05 | NRARP BMP4 ZC3H12A HGF NOTCH3 WNT11 ANGPT2 ALOX12 TBX4 GREB1L COL8A1 RSPO3 FGF18 GREM1 SIX2 SOX11 CCBE1 CREB3L1 JUP TBX1 |
Regulation of morphogenesis of an epithelium | 10 | 204 | 4.32E−05 | HGF BMP4 AJAP1 WNT11 ALOX12 FGF7 GREM1 ROR2 SIX2 RSPO3 |
Epidermis morphogenesis | 5 | 29 | 5.24E−05 | KLK14 KRT17 FGF7 TMEM79 KRT25 |
Angiogenesis | 15 | 511 | 5.42E−05 | NRARP BMP4 ZC3H12A HGF NOTCH3 ANGPT2 TBX4 COL8A1 RSPO3 FGF18 GREM1 CCBE1 CREB3L1 JUP TBX1 |
Cell migration | 27 | 1506 | 5.42E−05 | HGF SDC1 IL36G IL1RN DEFB4A RHOD MYOC ANGPT2 BMP4 FGF7 FGF18 S100A9 ZC3H12A ROR2 SIX2 WNT11 BDKRB1 SMPD3 ALOX12 CYP19A1 GREM1 CCBE1 LTB4R2 JUP TWIST2 TBX1 S100A12 |
Cell death | 36 | 2415 | 5.45E−05 | HGF BMP4 NGF ADAMTSL4 ZNF385B S100A9 ZC3H12A WNT11 ALOX12 ZBTB16 ID3 CREB3L1 TMEM79 GREM1 SOX11 TWIST2 CD36 SIK1 TBX1 PNMA5 TGM1 KRT37 PI3 KRT17 KLK14 TCHH KRT82 SPRR2D KLK13 KRT80 JUP KLK12 KRT25 SPINK9 KRT81 SPRR2A |
Respiratory system development | 10 | 215 | 6.07E−05 | BMP4 FGF7 SMPD3 DLX5 TBX4 FGF18 PKDCC SOX11 CCBE1 WNT11 |
Cartilage development | 10 | 216 | 6.17E−05 | ZBTB16 BMP4 PITX1 SMPD3 FGF18 PKDCC ROR2 SIX2 GREM1 WNT11 |
Positive regulation of ossification | 7 | 88 | 6.78E−05 | ZBTB16 BMP4 GDPD2 PKDCC ADRB2 SOX11 HGF |
Regulation of multicellular organismal development | 33 | 2138 | 7.25E−05 | ID3 NGF HEYL HGF ZBTB16 BMP4 IL1RN FGF7 ZC3H12A AJAP1 MAFB NOTCH3 WNT11 ANGPT2 SMPD3 ALOX12 KRT17 CHN1 FGF18 PKDCC GREM1 ROR2 ADRB2 SIX2 SOX11 CCBE1 NRARP CREB3L1 JUP SULT2B1 S100A9 TBX1 RSPO3 |
Blood vessel morphogenesis | 16 | 603 | 7.46E−5 | NRARP BMP4 ZC3H12A HGF NOTCH3 WNT11 ANGPT2 TBX4 COL8A1 RSPO3 FGF18 GREM1 CCBE1 CREB3L1 JUP TBX1 |
Programmed cell death | 34 | 2257 | 8.00E−05 | HGF BMP4 NGF ADAMTSL4 ZNF385B S100A9 WNT11 ALOX12 ZBTB16 ID3 CREB3L1 TMEM79 ZC3H12A GREM1 TWIST2 SIK1 TBX1 PNMA5 TGM1 KRT37 PI3 KRT17 KLK14 TCHH KRT82 SPRR2D KLK13 KRT80 JUP KLK12 KRT25 SPINK9 KRT81 SPRR2A |
Blood vessel development | 17 | 687 | 8.58E−05 | HEYL NRARP BMP4 ZC3H12A HGF NOTCH3 WNT11 ANGPT2 TBX4 COL8A1 RSPO3 FGF18 GREM1 CCBE1 CREB3L1 JUP TBX1 |
Embryonic morphogenesis | 16 | 615 | 8.98E−05 | BMP4 IL1RN PITX1 WNT11 DLX5 ZBTB16 MDFI TBX4 RSPO3 GREM1 ROR2 SIX2 SOX11 MAFB COL8A1 TBX1 |
Cell motility | 28 | 1670 | 9.30E−05 | HGF SDC1 IL36G IL1RN DEFB4A RHOD MYOC ANGPT2 BMP4 FGF7 FGF18 S100A9 ZC3H12A ROR2 SIX2 WNT11 BDKRB1 SMPD3 ALOX12 CYP19A1 GREM1 CCBE1 LTB4R2 DUOX1 JUP TWIST2 TBX1 S100A12 |
Localization of cell | 28 | 1670 | 9.30E−05 | HGF SDC1 IL36G IL1RN DEFB4A RHOD MYOC ANGPT2 BMP4 FGF7 FGF18 S100A9 ZC3H12A ROR2 SIX2 WNT11 BDKRB1 SMPD3 ALOX12 CYP19A1 GREM1 CCBE1 LTB4R2 DUOX1 JUP TWIST2 TBX1 S100A12 |
Cellular response to growth factor stimulus | 17 | 694 | 9.30E−05 | HGF BMP4 NGF FGF18 CREB3L1 GREM1 CCBE1 FAM83G ANGPT2 SMPD3 DLX5 RASL11B FGF7 HEYL ROR2 SOX11 TBX1 |
Cell–cell signaling | 29 | 1774 | 9.65E−05 | WNT11 CHRNA4 NGF RSPO3 NRARP JUP HGF CYP19A1 GREM1 FAM3D SLC8A3 SMPD3 DLX5 SDC1 BMP4 IL1RN FGF7 ROR2 ADRB2 SOX11 LYNX1 MYOC G6PC2 MDFI GLP1R IL36G FGF18 S100A9 ADRA1D |
Tissue migration | 11 | 293 | 1.10E−04 | ANGPT2 BMP4 FGF7 FGF18 ZC3H12A ALOX12 GREM1 CCBE1 LTB4R2 JUP ACTG2 |
Appendage development | 9 | 186 | 1.10E−04 | PITX1 DLX5 ZBTB16 TBX4 BMP4 PKDCC GREM1 ROR2 SOX11 |
Limb development | 9 | 186 | 1.10E−04 | PITX1 DLX5 ZBTB16 TBX4 BMP4 PKDCC GREM1 ROR2 SOX11 |
Lung development | 9 | 188 | 1.18E−04 | BMP4 FGF7 SMPD3 TBX4 FGF18 PKDCC SOX11 CCBE1 WNT11 |
Vasculature development | 17 | 715 | 1.20E−04 | HEYL NRARP BMP4 ZC3H12A HGF NOTCH3 WNT11 ANGPT2 TBX4 COL8A1 RSPO3 FGF18 GREM1 CCBE1 CREB3L1 JUP TBX1 |
Respiratory tube development | 9 | 192 | 1.34E−04 | BMP4 FGF7 SMPD3 TBX4 FGF18 PKDCC SOX11 CCBE1 WNT11 |
Response to growth factor | 17 | 723 | 1.34E−04 | HGF BMP4 NGF FGF18 CREB3L1 GREM1 CCBE1 FAM83G ANGPT2 SMPD3 DLX5 RASL11B FGF7 HEYL ROR2 SOX11 TBX1 |
Cardiovascular system development | 17 | 724 | 1.34E−04 | HEYL NRARP BMP4 ZC3H12A HGF NOTCH3 WNT11 ANGPT2 TBX4 COL8A1 RSPO3 FGF18 GREM1 CCBE1 CREB3L1 JUP TBX1 |
Locomotion | 30 | 1921 | 1.34E−04 | HGF SDC1 IL36G IL1RN DEFB4A RHOD MYOC ANGPT2 BMP4 FGF7 FGF18 S100A9 ZC3H12A ROR2 SIX2 WNT11 BDKRB1 SMPD3 DLX5 ALOX12 CHN1 CYP19A1 GREM1 CCBE1 LTB4R2 DUOX1 JUP TWIST2 TBX1 S100A12 |
Mesonephros development | 7 | 104 | 1.40E−04 | BMP4 ZBTB16 SDC1 GREB1L GREM1 SIX2 WNT11 |
Positive regulation of developmental process | 25 | 1433 | 1.40E−04 | NGF MYOC ZBTB16 BMP4 FGF7 ZC3H12A HGF ANGPT2 ALOX12 KRT17 GDPD2 CD36 FGF18 PKDCC TMEM79 HEYL GREM1 ROR2 ADRB2 SOX11 CCBE1 JUP SULT2B1 S100A9 TBX1 |
Nephron development | 8 | 147 | 1.41E−04 | BMP4 NOTCH3 ANGPT2 GREB1L HEYL GREM1 SIX2 WNT11 |
Positive regulation of cell communication | 30 | 1937 | 1.48E−04 | BMP4 IL36G IL1RN RSPO3 NRARP JUP HGF MYOC KLK14 CYP19A1 FGF18 S100A9 S100A12 ZC3H12A ADRB2 ALOX12B CCBE1 SLC8A3 DLX5 CHN1 CD36 GREM1 ROR2 SOX11 WNT11 SH3RF3 NGF TBX1 FGF7 ELF3 |
Positive regulation of signaling | 30 | 1945 | 1.56E−04 | BMP4 IL36G IL1RN RSPO3 NRARP JUP HGF MYOC KLK14 CYP19A1 FGF18 S100A9 S100A12 ZC3H12A ADRB2 ALOX12B CCBE1 SLC8A3 DLX5 CHN1 CD36 GREM1 ROR2 SOX11 WNT11 SH3RF3 NGF TBX1 FGF7 ELF3 |
Circulatory system development | 21 | 1077 | 1.56E−04 | HEYL NRARP BMP4 ZC3H12A HGF NOTCH3 WNT11 ANGPT2 ID3 TBX4 GREB1L COL8A1 RSPO3 FGF18 GREM1 SOX11 CCBE1 CREB3L1 JUP TBX1 SIK1 |
Positive regulation of signal transduction | 28 | 1762 | 1.91E−04 | BMP4 IL36G IL1RN RSPO3 NRARP JUP HGF MYOC KLK14 FGF18 S100A9 S100A12 ZC3H12A ADRB2 ALOX12B CCBE1 DLX5 CHN1 CD36 GREM1 ROR2 SOX11 WNT11 SH3RF3 NGF TBX1 FGF7 ELF3 |
Ameboidal-type cell migration | 12 | 392 | 2.39E−04 | ANGPT2 BMP4 FGF7 FGF18 ZC3H12A WNT11 ALOX12 GREM1 CCBE1 LTB4R2 JUP TBX1 |
Regulation of osteoblast differentiation | 7 | 115 | 2.44E−04 | BMP4 TWIST2 ID3 GDPD2 GREM1 SOX11 HGF |
Bone mineralization | 7 | 116 | 2.55E−04 | BMP4 WNT11 SMPD3 PKDCC ROR2 ADRB2 GREM1 |
Establishment of skin barrier | 4 | 22 | 2.65E−04 | ALOX12 TMEM79 ALOX12B CLDN4 |
Regulation of cell motility | 19 | 946 | 2.69E−04 | HGF RHOD MYOC ANGPT2 BMP4 FGF7 FGF18 ZC3H12A ROR2 BDKRB1 SMPD3 ALOX12 CYP19A1 GREM1 CCBE1 DUOX1 JUP TWIST2 WNT11 |
Mesenchymal cell proliferation | 5 | 46 | 2.69E−04 | BMP4 FGF7 WNT11 SIX2 TBX1 |
Positive regulation of cell motility | 14 | 544 | 2.73E−04 | HGF MYOC BMP4 FGF7 FGF18 ZC3H12A ROR2 BDKRB1 ALOX12 CCBE1 DUOX1 TWIST2 WNT11 RHOD |
Response to BMP | 8 | 165 | 2.73E−04 | BMP4 GREM1 FAM83G SMPD3 DLX5 HEYL ROR2 SOX11 |
Cellular response to BMP stimulus | 8 | 165 | 2.73E−04 | BMP4 GREM1 FAM83G SMPD3 DLX5 HEYL ROR2 SOX11 |
Biomineral tissue development | 8 | 167 | 2.93E−04 | BMP4 WNT11 SMPD3 PKDCC ROR2 ADRB2 GREM1 TBX1 |
Connective tissue development | 10 | 280 | 3.18E−04 | ZBTB16 BMP4 PITX1 SMPD3 FGF18 PKDCC ROR2 SIX2 GREM1 WNT11 |
Regulation of animal organ morphogenesis | 10 | 281 | 3.22E−04 | HGF BMP4 FGF7 AJAP1 WNT11 GREM1 ROR2 SIX2 TBX1 RSPO3 |
Embryo development | 20 | 1054 | 3.22E−04 | BMP4 IL1RN PITX1 WNT11 DLX5 ZBTB16 MDFI ID3 TBX4 RSPO3 PKDCC ELF3 GREM1 ROR2 SIX2 SOX11 NRARP MAFB COL8A1 TBX1 |
Chondrocyte differentiation | 7 | 123 | 3.22E−04 | SMPD3 BMP4 FGF18 PKDCC SIX2 ZBTB16 GREM1 |
Epithelial cell migration | 10 | 284 | 3.33E−04 | ANGPT2 BMP4 FGF7 FGF18 ZC3H12A ALOX12 GREM1 CCBE1 LTB4R2 JUP |
Regulation of cell migration | 18 | 883 | 3.33E−04 | HGF RHOD MYOC ANGPT2 BMP4 FGF7 FGF18 ZC3H12A ROR2 BDKRB1 SMPD3 ALOX12 CYP19A1 GREM1 CCBE1 JUP TWIST2 WNT11 |
Positive regulation of cellular component movement | 14 | 558 | 3.33E−04 | HGF MYOC BMP4 FGF7 FGF18 ZC3H12A ROR2 BDKRB1 ALOX12 CCBE1 DUOX1 TWIST2 WNT11 RHOD |
Epithelium migration | 10 | 287 | 3.60E−04 | ANGPT2 BMP4 FGF7 FGF18 ZC3H12A ALOX12 GREM1 CCBE1 LTB4R2 JUP |
Hair follicle morphogenesis | 4 | 25 | 3.68E−04 | KRT17 FGF7 TMEM79 KRT25 |
Regulation of water loss via skin | 4 | 25 | 3.68E−04 | ALOX12 TMEM79 ALOX12B CLDN4 |
Embryonic limb morphogenesis | 7 | 130 | 4.20E−04 | PITX1 DLX5 ZBTB16 TBX4 BMP4 GREM1 ROR2 |
Embryonic appendage morphogenesis | 7 | 130 | 4.20E−04 | PITX1 DLX5 ZBTB16 TBX4 BMP4 GREM1 ROR2 |
Positive regulation of locomotion | 14 | 576 | 4.34E−04 | HGF MYOC BMP4 FGF7 FGF18 ZC3H12A ROR2 BDKRB1 ALOX12 CCBE1 DUOX1 TWIST2 WNT11 RHOD |
Endochondral ossification | 4 | 27 | 4.78E−04 | SMPD3 DLX5 BMP4 FGF18 |
Replacement ossification | 4 | 27 | 4.78E−04 | SMPD3 DLX5 BMP4 FGF18 |
Positive regulation of MAPK cascade | 14 | 583 | 4.79E−04 | IL36G IL1RN BMP4 FGF18 ZC3H12A ADRB2 ALOX12B HGF CD36 ROR2 SH3RF3 TBX1 NGF S100A12 |
Poly-N-acetyllactosamine biosynthetic process | 3 | 10 | 5.48E−04 | B3GNT4 B3GNT8 B3GNT3 |
Regulation of multicellular organismal process | 41 | 3382 | 5.95E−04 | ID3 NGF IL36G IL1RN HEYL AVPR1A ADRB2 HGF ANGPT2 ZBTB16 BMP4 FGF7 FGF18 ZC3H12A CCBE1 AJAP1 MAFB TWIST2 NOTCH3 WNT11 SLC8A3 SMPD3 ALOX12 GLP1R KRT17 CHN1 GDPD2 CD36 PKDCC GREM1 ROR2 SIX2 SOX11 NRARP CREB3L1 JUP SULT2B1 ALOX12B S100A9 TBX1 RSPO3 |
Response to endogenous stimulus | 26 | 1704 | 5.97E−04 | BMP4 NGF AVPR1A IL1RN FGF18 CREB3L1 HEYL GREM1 JUP FAM83G SLC8A3 CHRNA4 SMPD3 DLX5 GLP1R SDC1 RASL11B CD36 FGF7 ROR2 ADRB2 SOX11 CLDN4 TBX1 GNA15 CATSPERB |
Positive regulation of cell migration | 13 | 521 | 6.09E−04 | HGF MYOC BMP4 FGF7 FGF18 ZC3H12A ROR2 BDKRB1 ALOX12 CCBE1 TWIST2 WNT11 RHOD |
Chemotaxis | 15 | 680 | 6.18E−04 | IL36G IL1RN DEFB4A HGF ANGPT2 FGF7 FGF18 S100A9 DLX5 BMP4 CHN1 CYP19A1 GREM1 S100A12 LTB4R2 |
Regulation of cellular component movement | 19 | 1028 | 6.21E−04 | HGF RHOD MYOC ANGPT2 BMP4 FGF7 FGF18 ZC3H12A ROR2 BDKRB1 SMPD3 ALOX12 CYP19A1 GREM1 CCBE1 DUOX1 JUP TWIST2 WNT11 |
Movement of cell or subcellular component | 30 | 2139 | 6.25E−04 | HGF SDC1 IL36G IL1RN DEFB4A RHOD MYOC ANGPT2 BMP4 FGF7 FGF18 S100A9 ZC3H12A ROR2 SIX2 WNT11 BDKRB1 SMPD3 DLX5 ALOX12 CHN1 CYP19A1 GREM1 CCBE1 LTB4R2 DUOX1 JUP TWIST2 TBX1 S100A12 |
Taxis | 15 | 683 | 6.25E−04 | IL36G IL1RN DEFB4A HGF ANGPT2 FGF7 FGF18 S100A9 DLX5 BMP4 CHN1 CYP19A1 GREM1 S100A12 LTB4R2 |
Nephron tubule development | 6 | 96 | 6.25E−04 | BMP4 GREB1L HEYL GREM1 SIX2 WNT11 |
Embryonic organ development | 12 | 452 | 6.34E−04 | WNT11 DLX5 MDFI ID3 BMP4 RSPO3 PKDCC ROR2 SIX2 SOX11 MAFB TBX1 |
Morphogenesis of a branching epithelium | 8 | 194 | 6.34E−04 | NRARP HGF BMP4 FGF7 GREB1L RSPO3 GREM1 SIX2 |
Kidney epithelium development | 7 | 143 | 6.55E−04 | BMP4 SDC1 GREB1L HEYL GREM1 SIX2 WNT11 |
Poly-N-acetyllactosamine metabolic process | 3 | 11 | 6.64E−04 | B3GNT4 B3GNT8 B3GNT3 |
Positive regulation of intracellular signal transduction | 20 | 1133 | 6.72E−04 | IL36G IL1RN HGF MYOC BMP4 FGF18 S100A9 S100A12 ZC3H12A ADRB2 ALOX12B CD36 GREM1 ROR2 SOX11 WNT11 SH3RF3 NGF TBX1 FGF7 |
Regulation of locomotion | 19 | 1041 | 6.74E−04 | HGF RHOD MYOC ANGPT2 BMP4 FGF7 FGF18 ZC3H12A ROR2 BDKRB1 SMPD3 ALOX12 CYP19A1 GREM1 CCBE1 DUOX1 JUP TWIST2 WNT11 |
Ureteric bud development | 6 | 99 | 6.85E−04 | BMP4 SDC1 GREB1L GREM1 SIX2 WNT11 |
Renal tubule development | 6 | 99 | 6.85E−04 | BMP4 GREB1L HEYL GREM1 SIX2 WNT11 |
Positive regulation of cartilage development | 4 | 31 | 6.94E−04 | ZBTB16 BMP4 FGF18 PKDCC |
Mesonephric epithelium development | 6 | 100 | 7.06E−04 | BMP4 SDC1 GREB1L GREM1 SIX2 WNT11 |
Mesonephric tubule development | 6 | 100 | 7.06E−04 | BMP4 SDC1 GREB1L GREM1 SIX2 WNT11 |
Positive regulation of gene expression | 29 | 2060 | 7.22E−04 | DLX5 ZBTB16 HEYL JUP SOX11 BMP4 ELF3 ZC3H12A CCBE1 PITX1 NOTCH3 ALOX12 KRT17 CD36 FGF7 CREB3L1 GREM1 ROR2 ADRB2 SIX2 OVOL1 MAFB WNT11 NGF ALOX12B GLIS3 ACTG2 TBX1 HGF |
Regulation of morphogenesis of a branching structure | 5 | 63 | 7.98E−04 | HGF BMP4 FGF7 GREM1 SIX2 |
BMP signaling pathway | 7 | 152 | 8.66E−04 | BMP4 GREM1 FAM83G SMPD3 DLX5 ROR2 SOX11 |
Endothelial cell migration | 8 | 206 | 8.66E−04 | ANGPT2 BMP4 FGF18 ZC3H12A ALOX12 GREM1 CCBE1 JUP |
Morphogenesis of a branching structure | 8 | 208 | 9.13E−04 | NRARP HGF BMP4 FGF7 GREB1L RSPO3 GREM1 SIX2 |
Mesenchymal to epithelial transition involved in metanephros morphogenesis | 3 | 13 | 1.01E−03 | BMP4 GREM1 SIX2 |
Mesenchymal cell differentiation | 8 | 212 | 1.01E−03 | WNT11 BMP4 HEYL SIX2 SOX11 GREM1 TBX1 HGF |
Mesenchyme development | 9 | 273 | 1.01E−03 | WNT11 BMP4 HEYL SIX2 SOX11 GREM1 ACTG2 TBX1 HGF |
Ureteric bud morphogenesis | 5 | 67 | 1.01E−03 | BMP4 GREB1L GREM1 SIX2 WNT11 |
Mesonephric tubule morphogenesis | 5 | 68 | 1.08E−03 | BMP4 GREB1L GREM1 SIX2 WNT11 |
Regulation of cell-substrate adhesion | 8 | 216 | 1.13E−03 | MYOC CD36 AJAP1 ANGPT2 COL8A1 GREM1 RHOD JUP |
Regulation of endothelial cell migration | 7 | 161 | 1.16E−03 | ANGPT2 BMP4 FGF18 ZC3H12A ALOX12 CCBE1 JUP |
Positive regulation of multicellular organismal process | 27 | 1911 | 1.17E−03 | NGF IL36G IL1RN AVPR1A ZBTB16 BMP4 FGF7 FGF18 ZC3H12A CCBE1 HGF WNT11 ANGPT2 ALOX12 KRT17 GDPD2 CD36 PKDCC HEYL GREM1 ROR2 ADRB2 SOX11 JUP ALOX12B S100A9 TBX1 |
Nephron epithelium development | 6 | 112 | 1.18E−03 | BMP4 GREB1L HEYL GREM1 SIX2 WNT11 |
Regulation of epithelial cell migration | 8 | 223 | 1.36E−03 | ANGPT2 BMP4 FGF7 FGF18 ZC3H12A ALOX12 CCBE1 JUP |
Positive regulation of epidermis development | 4 | 38 | 1.36E−03 | BMP4 KRT17 TMEM79 SULT2B1 |
Aminoglycan biosynthetic process | 6 | 116 | 1.39E−03 | B3GNT4 B3GNT8 B3GNT3 SMPD3 SDC1 HS3ST3A1 |
Positive regulation of angiogenesis | 7 | 167 | 1.39E−03 | ZC3H12A HGF ANGPT2 GREM1 CCBE1 FGF18 JUP |
Sprouting angiogenesis | 6 | 117 | 1.45E−03 | NRARP BMP4 RSPO3 GREM1 CREB3L1 CCBE1 |
Cell-substrate adhesion | 10 | 358 | 1.46E−03 | LYPD3 LYPD5 MYOC CD36 AJAP1 ANGPT2 COL8A1 GREM1 RHOD JUP |
Sulfate assimilation | 2 | 3 | 1.52E−03 | PAPSS2 SULT2B1 |
Cuticle development | 2 | 3 | 1.52E−03 | TMEM79 DUOX1 |
Cloacal septation | 2 | 3 | 1.52E−03 | BMP4 WNT11 |
Aminoglycan metabolic process | 7 | 171 | 1.53E−03 | B3GNT4 B3GNT8 B3GNT3 HGF SMPD3 SDC1 HS3ST3A1 |
Cardiac septum morphogenesis | 5 | 75 | 1.53E−03 | HEYL WNT11 BMP4 SOX11 TBX1 |
Cellular response to endogenous stimulus | 22 | 1432 | 1.61E−03 | BMP4 NGF AVPR1A FGF18 CREB3L1 HEYL GREM1 JUP FAM83G SLC8A3 CHRNA4 SMPD3 DLX5 GLP1R RASL11B FGF7 ROR2 ADRB2 SOX11 CD36 TBX1 GNA15 |
Nephron tubule morphogenesis | 5 | 76 | 1.61E−03 | BMP4 GREB1L GREM1 SIX2 WNT11 |
Metanephric renal vesicle morphogenesis | 3 | 16 | 1.65E−03 | BMP4 GREM1 SIX2 |
Regulation of cell–matrix adhesion | 6 | 122 | 1.68E−03 | MYOC CD36 AJAP1 GREM1 RHOD JUP |
Outflow tract morphogenesis | 5 | 77 | 1.68E−03 | WNT11 BMP4 HEYL SOX11 TBX1 |
Nephron epithelium morphogenesis | 5 | 78 | 1.77E−03 | BMP4 GREB1L GREM1 SIX2 WNT11 |
Ventricular septum morphogenesis | 4 | 42 | 1.79E−03 | HEYL WNT11 BMP4 SOX11 |
Cell–matrix adhesion | 8 | 239 | 1.91E−03 | LYPD3 LYPD5 MYOC CD36 AJAP1 GREM1 RHOD JUP |
Embryonic organ morphogenesis | 9 | 305 | 1.91E−03 | WNT11 DLX5 MDFI BMP4 ROR2 SIX2 SOX11 MAFB TBX1 |
Renal tubule morphogenesis | 5 | 80 | 1.91E−03 | BMP4 GREB1L GREM1 SIX2 WNT11 |
Nephron morphogenesis | 5 | 80 | 1.91E−03 | BMP4 GREB1L GREM1 SIX2 WNT11 |
Nephric duct development | 3 | 17 | 1.91E−03 | BMP4 GREB1L WNT11 |
Regulation of cell communication | 43 | 3903 | 2.15E−03 | BMP4 NGF IL36G IL1RN SIK1 RSPO3 NRARP JUP HGF MYOC KLK14 CYP19A1 FGF18 CREB3L1 S100A9 S100A12 ZC3H12A HEYL GREM1 ADRB2 ALOX12B LYNX1 CCBE1 FAM3D WNT11 SLC8A3 CHRNA4 DLX5 RASL11B CHN1 CD36 FGF7 AVPR1A ROR2 SOX11 G6PC2 SH3RF3 MDFI TBX1 NOTCH3 GLP1R ELF3 RHOD |
Enzyme linked receptor protein signaling pathway | 18 | 1072 | 2.17E−03 | HGF BMP4 NGF ROR2 ANGPT2 CREB3L1 GREM1 CCBE1 FAM83G MYOC SMPD3 DLX5 RASL11B FGF7 FGF18 SOX11 CHN1 ADRB2 |
Regulation of MAPK cascade | 15 | 793 | 2.17E−03 | BMP4 IL36G IL1RN MYOC FGF18 ZC3H12A ADRB2 ALOX12B HGF CD36 ROR2 SH3RF3 TBX1 NGF S100A12 |
Embryonic skeletal system development | 6 | 130 | 2.21E−03 | MDFI BMP4 SIX2 SOX11 WNT11 TBX1 |
Positive regulation of vasculature development | 7 | 186 | 2.29E−03 | ZC3H12A HGF ANGPT2 GREM1 CCBE1 FGF18 JUP |
Response to organic substance | 40 | 3547 | 2.30E−03 | HGF BMP4 NGF IL36G IL1RN AVPR1A CD36 DUOX1 FGF18 CREB3L1 ZC3H12A HEYL GREM1 JUP CCBE1 FAM83G ANGPT2 SLC8A3 BDKRB1 CHRNA4 SMPD3 DLX5 ALOX12 GLP1R SDC1 ID3 SLPI RASL11B FGF7 ROR2 ADRB2 ABCG4 SOX11 CLDN4 WNT11 TBX1 GNA15 CATSPERB HSPB3 GPX3 |
Positive chemotaxis | 5 | 84 | 2.30E−03 | ANGPT2 FGF7 HGF BMP4 DEFB4A |
Response to psychosocial stress | 2 | 4 | 2.56E−03 | GLP1R ADRB2 |
Cloaca development | 2 | 4 | 2.56E−03 | BMP4 WNT11 |
Positive regulation of epithelial cell proliferation | 7 | 190 | 2.56E−03 | NRARP BMP4 FGF7 DLX5 SOX11 TGM1 TBX1 |
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling | 2 | 4 | 2.56E−03 | HGF FGF7 |
Myoblast differentiation | 5 | 87 | 2.62E−03 | BMP4 PITX1 SDC1 ID3 GREM1 |
Regulation of signaling | 43 | 3952 | 2.64E−03 | BMP4 NGF IL36G IL1RN SIK1 RSPO3 NRARP JUP HGF MYOC KLK14 CYP19A1 FGF18 CREB3L1 S100A9 S100A12 ZC3H12A HEYL GREM1 ADRB2 ALOX12B LYNX1 CCBE1 FAM3D WNT11 SLC8A3 CHRNA4 DLX5 RASL11B CHN1 CD36 FGF7 AVPR1A ROR2 SOX11 G6PC2 SH3RF3 MDFI TBX1 NOTCH3 GLP1R ELF3 RHOD |
Negative regulation of transcription, DNA-templated | 20 | 1298 | 2.73E−03 | ZBTB16 BMP4 SIX2 OVOL1 SOX11 ZNF154 ID3 CREB3L1 ELF3 HEYL PITX1 NOTCH3 CD36 GREM1 NRARP USP2 WNT11 GLIS3 MDFI TWIST2 |
Positive regulation of chondrocyte differentiation | 3 | 20 | 2.78E−03 | FGF18 PKDCC ZBTB16 |
Mesenchymal to epithelial transition | 3 | 20 | 2.78E−03 | BMP4 GREM1 SIX2 |
Renal vesicle morphogenesis | 3 | 20 | 2.78E−03 | BMP4 GREM1 SIX2 |
Response to oxygen-containing compound | 24 | 1725 | 2.88E−03 | IL36G IL1RN HGF DUOX1 ZC3H12A JUP ANGPT2 SLC8A3 BDKRB1 CHRNA4 SMPD3 GLP1R SDC1 ID3 SLPI CD36 AVPR1A ADRB2 CLDN4 WNT11 TBX1 GNA15 CATSPERB GPX3 |
Regulation of vasculature development | 9 | 328 | 2.89E−03 | BMP4 ZC3H12A HGF ANGPT2 GREM1 CCBE1 FGF18 CREB3L1 JUP |
Digestive tract morphogenesis | 4 | 50 | 3.01E−03 | BMP4 SIX2 SOX11 WNT11 |
Metanephros development | 5 | 91 | 3.04E−03 | BMP4 ID3 GREB1L GREM1 SIX2 |
Positive regulation of epithelial cell migration | 6 | 141 | 3.04E−03 | BMP4 FGF7 FGF18 ZC3H12A ALOX12 CCBE1 |
Regulation of cell differentiation | 26 | 1954 | 3.04E−03 | ID3 NGF HEYL MYOC BMP4 ZC3H12A AJAP1 MAFB TWIST2 HGF NOTCH3 ZBTB16 CHN1 GDPD2 CD36 FGF18 PKDCC GREM1 ROR2 SIX2 SOX11 NRARP SULT2B1 SIK1 S100A9 TBX1 |
Copulation | 3 | 21 | 3.06E−03 | KLK14 PI3 AVPR1A |
Positive regulation of cell differentiation | 17 | 1018 | 3.06E−03 | NGF MYOC BMP4 ZC3H12A HGF ZBTB16 GDPD2 CD36 FGF18 PKDCC HEYL GREM1 ROR2 SOX11 SULT2B1 S100A9 TBX1 |
Renal vesicle development | 3 | 21 | 3.06E−03 | BMP4 GREM1 SIX2 |
Cell surface receptor signaling pathway involved in cell–cell signaling | 13 | 654 | 3.16E−03 | WNT11 RSPO3 NRARP JUP GREM1 CHRNA4 DLX5 SDC1 ROR2 ADRB2 MYOC BMP4 MDFI |
Roof of mouth development | 5 | 93 | 3.25E−03 | WNT11 DLX5 PKDCC SOX11 TBX1 |
Leukocyte migration | 11 | 491 | 3.36E−03 | IL36G IL1RN S100A9 BDKRB1 SMPD3 CYP19A1 GREM1 ROR2 ANGPT2 SDC1 S100A12 |
Cell chemotaxis | 9 | 339 | 3.45E−03 | IL36G IL1RN DEFB4A HGF FGF18 S100A9 CYP19A1 GREM1 S100A12 |
Sensory organ morphogenesis | 8 | 270 | 3.53E−03 | DLX5 BMP4 COL8A1 ROR2 SIX2 SOX11 MAFB TBX1 |
Negative regulation of cellular biosynthetic process | 23 | 1658 | 3.67E−03 | ZBTB16 BMP4 SIX2 OVOL1 SOX11 ZNF154 ID3 CREB3L1 ELF3 ZC3H12A HEYL PITX1 NOTCH3 SMPD3 CD36 GREM1 NRARP USP2 WNT11 GLIS3 MDFI SIK1 TWIST2 |
Hepoxilin metabolic process | 2 | 5 | 3.67E−03 | ALOX12 ALOX12B |
Hepoxilin biosynthetic process | 2 | 5 | 3.67E−03 | ALOX12 ALOX12B |
Glomerulus vasculature morphogenesis | 2 | 5 | 3.67E−03 | NOTCH3 BMP4 |
Glomerular capillary formation | 2 | 5 | 3.67E−03 | NOTCH3 BMP4 |
Negative regulation of RNA metabolic process | 21 | 1446 | 3.68E−03 | ZBTB16 BMP4 SIX2 OVOL1 SOX11 ZNF154 ID3 CREB3L1 ELF3 ZC3H12A HEYL PITX1 NOTCH3 CD36 GREM1 NRARP USP2 WNT11 GLIS3 MDFI TWIST2 |
Embryonic skeletal system morphogenesis | 5 | 97 | 3.70E−03 | MDFI BMP4 SIX2 SOX11 TBX1 |
Kidney morphogenesis | 5 | 97 | 3.70E−03 | BMP4 GREB1L GREM1 SIX2 WNT11 |
Cellular response to chemical stimulus | 39 | 3536 | 3.70E−03 | HGF BMP4 NGF IL36G IL1RN AVPR1A DEFB4A DUOX1 FGF18 CREB3L1 S100A9 S100A12 ZC3H12A HEYL GREM1 JUP CCBE1 FAM83G ANGPT2 SLC8A3 CHRNA4 SMPD3 DLX5 ALOX12 GLP1R ID3 RASL11B CD36 CYP19A1 FGF7 ROR2 ADRB2 ABCG4 SOX11 GPX3 WNT11 TBX1 GNA15 SDC1 |
Positive regulation of endothelial cell migration | 5 | 98 | 3.86E−03 | BMP4 FGF18 ZC3H12A ALOX12 CCBE1 |
Regulation of cell adhesion | 14 | 765 | 3.94E−03 | MYOC CD36 IL1RN AJAP1 ANGPT2 ALOX12 ZBTB16 COL8A1 ZC3H12A GREM1 RHOD NRARP JUP BMP4 |
Negative regulation of nucleic acid-templated transcription | 20 | 1353 | 3.96E−03 | ZBTB16 BMP4 SIX2 OVOL1 SOX11 ZNF154 ID3 CREB3L1 ELF3 HEYL PITX1 NOTCH3 CD36 GREM1 NRARP USP2 WNT11 GLIS3 MDFI TWIST2 |
Cellular response to organic substance | 34 | 2938 | 3.99E−03 | HGF BMP4 NGF IL36G IL1RN AVPR1A DUOX1 FGF18 CREB3L1 ZC3H12A HEYL GREM1 JUP CCBE1 FAM83G ANGPT2 SLC8A3 CHRNA4 SMPD3 DLX5 ALOX12 GLP1R ID3 RASL11B CD36 FGF7 ROR2 ADRB2 ABCG4 SOX11 WNT11 TBX1 GNA15 SDC1 |
Negative regulation of RNA biosynthetic process | 20 | 1355 | 3.99E−03 | ZBTB16 BMP4 SIX2 OVOL1 SOX11 ZNF154 ID3 CREB3L1 ELF3 HEYL PITX1 NOTCH3 CD36 GREM1 NRARP USP2 WNT11 GLIS3 MDFI TWIST2 |
Regulation of branching involved in ureteric bud morphogenesis | 3 | 24 | 4.06E−03 | BMP4 GREM1 SIX2 |
Intermediate filament organization | 3 | 24 | 4.06E−03 | TCHH KRT17 KRT25 |
Positive regulation of transcription by RNA polymerase II | 19 | 1255 | 4.06E−03 | DLX5 ZBTB16 HEYL JUP SOX11 BMP4 ZC3H12A PITX1 NOTCH3 CREB3L1 ELF3 GREM1 ADRB2 SIX2 OVOL1 MAFB GLIS3 TBX1 HGF |
Glomerulus vasculature development | 3 | 24 | 4.06E−03 | BMP4 NOTCH3 ANGPT2 |
Negative regulation of biosynthetic process | 23 | 1681 | 4.10E−03 | ZBTB16 BMP4 SIX2 OVOL1 SOX11 ZNF154 ID3 CREB3L1 ELF3 ZC3H12A HEYL PITX1 NOTCH3 SMPD3 CD36 GREM1 NRARP USP2 WNT11 GLIS3 MDFI SIK1 TWIST2 |
Carbohydrate biosynthetic process | 7 | 214 | 4.10E−03 | G6PC2 B3GNT4 B3GNT8 B3GNT3 SMPD3 CHST8 SIK1 |
Positive regulation of protein phosphorylation | 17 | 1057 | 4.10E−03 | HGF BMP4 IL36G IL1RN FGF7 FGF18 ZC3H12A ADRB2 ALOX12B WNT11 CD36 GREM1 ROR2 SH3RF3 TBX1 NGF S100A12 |
Negative regulation of nucleobasE−containing compound metabolic process | 22 | 1575 | 4.15E−03 | ZBTB16 BMP4 SIX2 OVOL1 SOX11 ZNF154 ID3 CREB3L1 CDA ELF3 ZC3H12A HEYL PITX1 NOTCH3 CD36 GREM1 NRARP USP2 WNT11 GLIS3 MDFI TWIST2 |
Regionalization | 9 | 355 | 4.24E−03 | BMP4 ZBTB16 GREM1 ROR2 SIX2 NRARP MAFB MDFI TBX1 |
Regulation of protein import into nucleus | 4 | 58 | 4.41E−03 | BMP4 ZC3H12A JUP CD36 |
Negative regulation of macromolecule biosynthetic process | 22 | 1597 | 4.86E−03 | ZBTB16 BMP4 SIX2 OVOL1 SOX11 ZNF154 ID3 CREB3L1 ELF3 ZC3H12A HEYL PITX1 NOTCH3 SMPD3 CD36 GREM1 NRARP USP2 WNT11 GLIS3 MDFI TWIST2 |
Positive regulation of osteoblast differentiation | 4 | 60 | 4.86E−03 | BMP4 GDPD2 SOX11 HGF |
Positive regulation of transcription, DNA-templated | 22 | 1599 | 4.86E−03 | DLX5 ZBTB16 HEYL JUP SOX11 BMP4 ELF3 ZC3H12A PITX1 NOTCH3 FGF7 CREB3L1 GREM1 ROR2 ADRB2 SIX2 OVOL1 MAFB WNT11 GLIS3 TBX1 HGF |
Renal system vasculature development | 3 | 26 | 4.86E−03 | BMP4 NOTCH3 ANGPT2 |
Kidney vasculature development | 3 | 26 | 4.86E−03 | BMP4 NOTCH3 ANGPT2 |
Cell differentiation involved in metanephros development | 3 | 26 | 4.86E−03 | BMP4 GREM1 SIX2 |
Metanephric nephron morphogenesis | 3 | 26 | 4.86E−03 | BMP4 GREM1 SIX2 |
Glycosaminoglycan metabolic process | 6 | 161 | 4.99E−03 | HGF SMPD3 SDC1 HS3ST3A1 B3GNT4 B3GNT3 |
Regulation of protein import | 4 | 61 | 5.07E−03 | BMP4 ZC3H12A JUP CD36 |
Branching involved in ureteric bud morphogenesis | 4 | 61 | 5.07E−03 | BMP4 GREB1L GREM1 SIX2 |
Glomerulus development | 4 | 61 | 5.07E−03 | BMP4 NOTCH3 ANGPT2 HEYL |
Negative regulation of cartilage development | 3 | 27 | 5.28E−03 | BMP4 GREM1 WNT11 |
Regulation of mesonephros development | 3 | 27 | 5.28E−03 | BMP4 GREM1 SIX2 |
Bone development | 7 | 228 | 5.49E−03 | MYOC SMPD3 DLX5 BMP4 FGF18 PAPSS2 GREM1 |
Negative regulation of cellular macromolecule biosynthetic process | 21 | 1511 | 5.53E−03 | ZBTB16 BMP4 SIX2 OVOL1 SOX11 ZNF154 ID3 CREB3L1 ELF3 ZC3H12A HEYL PITX1 NOTCH3 CD36 GREM1 NRARP USP2 WNT11 GLIS3 MDFI TWIST2 |
Regulation of angiogenesis | 8 | 298 | 5.53E−03 | ZC3H12A HGF ANGPT2 GREM1 CCBE1 FGF18 CREB3L1 JUP |
Peptide cross-linking | 4 | 63 | 5.57E−03 | SPRR2D SPRR2A TGM1 PI3 |
Embryonic hindlimb morphogenesis | 3 | 28 | 5.73E−03 | PITX1 ZBTB16 BMP4 |
Secondary palate development | 3 | 28 | 5.73E−03 | SOX11 WNT11 TBX1 |
Glycosaminoglycan biosynthetic process | 5 | 111 | 5.78E−03 | SMPD3 SDC1 HS3ST3A1 B3GNT4 B3GNT3 |
Artery morphogenesis | 4 | 64 | 5.81E−03 | BMP4 NOTCH3 WNT11 TBX1 |
Regulation of localization | 33 | 2905 | 5.84E−03 | HGF RHOD MYOC ANGPT2 BMP4 CYP19A1 FGF7 FGF18 ZC3H12A ROR2 JUP FAM3D BDKRB1 CHRNA4 SMPD3 ALOX12 CD36 PKDCC AVPR1A GREM1 ADRB2 CLIC3 SOX11 CCBE1 KCNK12 DUOX1 TWIST2 WNT11 SDC1 G6PC2 ALOX12B SIK1 GLP1R |
Cardiac septum development | 5 | 112 | 5.93E−03 | HEYL WNT11 BMP4 SOX11 TBX1 |
Positive regulation of cellular biosynthetic process | 26 | 2082 | 5.95E−03 | DLX5 ZBTB16 HEYL JUP SOX11 HGF BMP4 ELF3 ZC3H12A GREM1 PITX1 NOTCH3 KRT17 CD36 FGF7 CREB3L1 AVPR1A ROR2 ADRB2 SIX2 OVOL1 MAFB WNT11 GLIS3 TBX1 SMPD3 |
Response to lipid | 16 | 1006 | 5.95E−03 | IL36G IL1RN ZC3H12A HEYL BDKRB1 ALOX12 SDC1 ID3 SLPI CD36 AVPR1A CLDN4 BMP4 WNT11 TBX1 CATSPERB |
MAPK cascade | 16 | 1007 | 5.97E−03 | BMP4 IL36G IL1RN MYOC FGF18 ZC3H12A ADRB2 ALOX12B HGF CD36 ROR2 SH3RF3 TBX1 NGF FGF7 S100A12 |
Negative regulation of cell adhesion | 8 | 304 | 5.99E−03 | MYOC IL1RN AJAP1 ANGPT2 ALOX12 ZC3H12A NRARP BMP4 |
Renal system vasculature morphogenesis | 2 | 7 | 6.07E−03 | NOTCH3 BMP4 |
Kidney vasculature morphogenesis | 2 | 7 | 6.07E−03 | NOTCH3 BMP4 |
Positive regulation of phosphorylation | 17 | 1111 | 6.10E−03 | HGF BMP4 IL36G IL1RN FGF7 FGF18 ZC3H12A ADRB2 ALOX12B WNT11 CD36 GREM1 ROR2 SH3RF3 TBX1 NGF S100A12 |
Regulation of cell proliferation | 23 | 1756 | 6.32E−03 | NRARP BMP4 FGF7 GREM1 JUP NOTCH3 WNT11 SMPD3 DLX5 ALOX12 ZBTB16 RARRES1 FGF18 AVPR1A SIX2 OVOL1 SOX11 SULT2B1 TGM1 ROR2 TBX1 NGF ADRA1D |
Negative regulation of nitrogen compound metabolic process | 30 | 2564 | 6.32E−03 | ZBTB16 BMP4 SIX2 OVOL1 SOX11 ZNF154 HGF ID3 CREB3L1 CDA ELF3 ZC3H12A HEYL GREM1 PITX1 NOTCH3 BDKRB1 SMPD3 PI3 SLPI NGF CD36 NRARP SPINK9 COL28A1 USP2 WNT11 GLIS3 MDFI TWIST2 |
Cardiac chamber development | 6 | 172 | 6.32E−03 | HEYL WNT11 BMP4 GREB1L SOX11 TBX1 |
Negative regulation of developmental process | 16 | 1017 | 6.40E−03 | ID3 BMP4 MAFB TWIST2 NOTCH3 ANGPT2 ZBTB16 ZC3H12A ADRB2 SIX2 SOX11 NRARP CREB3L1 GREM1 TBX1 WNT11 |
Signal transduction by protein phosphorylation | 16 | 1018 | 6.44E−03 | BMP4 IL36G IL1RN MYOC FGF18 ZC3H12A ADRB2 ALOX12B HGF CD36 ROR2 SH3RF3 TBX1 NGF FGF7 S100A12 |
Transmembrane receptor protein tyrosine kinase signaling pathway | 13 | 730 | 6.45E−03 | HGF NGF ROR2 ANGPT2 CREB3L1 CCBE1 MYOC SMPD3 FGF7 FGF18 GREM1 CHN1 ADRB2 |
Cell adhesion | 21 | 1541 | 6.46E−03 | LYPD3 LYPD5 MYOC CD36 IL1RN S100A9 JUP AJAP1 ANGPT2 ALOX12 ZBTB16 COL8A1 FBLIM1 ZC3H12A GREM1 RHOD NRARP COL28A1 BMP4 CLDN4 LRRN2 |
Epithelial cell proliferation | 9 | 387 | 6.56E−03 | NRARP BMP4 FGF7 HGF DLX5 COL8A1 SOX11 TGM1 TBX1 |
Biological adhesion | 21 | 1548 | 6.78E−03 | LYPD3 LYPD5 MYOC CD36 IL1RN S100A9 JUP AJAP1 ANGPT2 ALOX12 ZBTB16 COL8A1 FBLIM1 ZC3H12A GREM1 RHOD NRARP COL28A1 BMP4 CLDN4 LRRN2 |
Myeloid leukocyte migration | 7 | 241 | 6.79E−03 | IL36G IL1RN S100A9 CYP19A1 GREM1 ROR2 S100A12 |
Positive regulation of biosynthetic process | 26 | 2113 | 6.91E−03 | DLX5 ZBTB16 HEYL JUP SOX11 HGF BMP4 CREB3L1 ELF3 ZC3H12A GREM1 PITX1 NOTCH3 KRT17 CD36 FGF7 AVPR1A ROR2 ADRB2 SIX2 OVOL1 MAFB WNT11 GLIS3 TBX1 SMPD3 |
Blood vessel endothelial cell migration | 5 | 119 | 7.19E−03 | ANGPT2 ALOX12 GREM1 FGF18 JUP |
Mesenchymal cell differentiation involved in renal system development | 2 | 8 | 7.48E−03 | BMP4 SIX2 |
Mesenchymal-epithelial cell signaling | 2 | 8 | 7.48E−03 | HGF FGF7 |
Glomerulus morphogenesis | 2 | 8 | 7.48E−03 | NOTCH3 BMP4 |
Mesenchymal cell differentiation involved in kidney development | 2 | 8 | 7.48E−03 | BMP4 SIX2 |
Negative regulation of mesenchymal cell proliferation | 2 | 8 | 7.48E−03 | BMP4 WNT11 |
Negative regulation of cellular metabolic process | 31 | 2724 | 7.59E−03 | ZBTB16 BMP4 SIX2 OVOL1 SOX11 ZNF154 HGF ID3 CREB3L1 CDA ELF3 ZC3H12A HEYL GREM1 PITX1 NOTCH3 BDKRB1 SMPD3 PI3 SLPI NGF CD36 NRARP SPINK9 COL28A1 USP2 WNT11 GLIS3 MDFI SIK1 TWIST2 |
Multicellular organismal water homeostasis | 4 | 71 | 7.63E−03 | ALOX12 TMEM79 ALOX12B CLDN4 |
Endochondral bone morphogenesis | 4 | 72 | 8.01E−03 | SMPD3 DLX5 BMP4 FGF18 |
Metanephros morphogenesis | 3 | 33 | 8.15E−03 | BMP4 GREM1 SIX2 |
Positive regulation of nucleic acid-templated transcription | 22 | 1694 | 8.53E−03 | DLX5 ZBTB16 HEYL JUP SOX11 BMP4 ELF3 ZC3H12A PITX1 NOTCH3 FGF7 CREB3L1 GREM1 ROR2 ADRB2 SIX2 OVOL1 MAFB WNT11 GLIS3 TBX1 HGF |
Positive regulation of RNA biosynthetic process | 22 | 1695 | 8.56E−03 | DLX5 ZBTB16 HEYL JUP SOX11 BMP4 ELF3 ZC3H12A PITX1 NOTCH3 FGF7 CREB3L1 GREM1 ROR2 ADRB2 SIX2 OVOL1 MAFB WNT11 GLIS3 TBX1 HGF |
Positive regulation of morphogenesis of an epithelium | 3 | 34 | 8.72E−03 | ALOX12 BMP4 GREM1 |
Regulation of mesenchymal cell proliferation | 3 | 34 | 8.72E−03 | BMP4 WNT11 TBX1 |
Ventricular septum development | 4 | 74 | 8.72E−03 | HEYL WNT11 BMP4 SOX11 |
Ear morphogenesis | 5 | 127 | 9.06E−03 | DLX5 ROR2 SIX2 MAFB TBX1 |
Cell proliferation | 26 | 2165 | 9.07E−03 | NRARP DLX5 BMP4 FGF7 GREM1 SIX2 JUP HGF NOTCH3 WNT11 SMPD3 ALOX12 ZBTB16 RARRES1 COL8A1 FGF18 AVPR1A OVOL1 SOX11 SULT2B1 TGM1 SDCBP2 ROR2 TBX1 NGF ADRA1D |
Soft palate development | 2 | 9 | 9.07E−03 | SOX11 TBX1 |
Regulation of branching involved in salivary gland morphogenesis | 2 | 9 | 9.07E−03 | HGF FGF7 |
Mesonephric duct development | 2 | 9 | 9.07E−03 | GREB1L WNT11 |
Regulation of DNA-binding transcription factor activity | 10 | 495 | 9.09E−03 | ID3 ZC3H12A HEYL JUP GREM1 CD36 SIK1 MDFI S100A9 S100A12 |
Regulation of hormone levels | 11 | 583 | 9.12E−03 | CYP19A1 FAM3D SMPD3 IL1RN DUOX1 CRABP1 SOX11 CHST8 G6PC2 GLP1R NGF |
Water homeostasis | 4 | 76 | 9.28E−03 | ALOX12 TMEM79 ALOX12B CLDN4 |
Cellular response to toxic substance | 7 | 259 | 9.32E−03 | HGF SMPD3 CD36 DUOX1 S100A9 ZC3H12A GPX3 |
Cardiac chamber morphogenesis | 5 | 129 | 9.38E−03 | HEYL WNT11 BMP4 SOX11 TBX1 |
Cardiac ventricle development | 5 | 130 | 9.67E−03 | HEYL WNT11 BMP4 GREB1L SOX11 |
Regulation of signal transduction | 37 | 3529 | 9.74E−03 | BMP4 IL36G IL1RN SIK1 RSPO3 NRARP JUP HGF MYOC KLK14 FGF18 CREB3L1 S100A9 S100A12 ZC3H12A HEYL GREM1 ADRB2 ALOX12B LYNX1 CCBE1 WNT11 DLX5 RASL11B CHN1 NGF CD36 FGF7 ROR2 SOX11 FAM3D SH3RF3 MDFI TBX1 NOTCH3 ELF3 RHOD |
Hindlimb morphogenesis | 3 | 36 | 9.82E−03 | PITX1 ZBTB16 BMP4 |
Odontogenesis | 5 | 131 | 9.89E−03 | SMPD3 SDC1 ID3 BMP4 TBX1 |
Regulation of bone mineralization | 4 | 78 | 9.90E−03 | BMP4 PKDCC ADRB2 GREM1 |
Polysaccharide biosynthetic process | 4 | 78 | 9.90E−03 | B3GNT4 B3GNT8 B3GNT3 SMPD3 |
Negative regulation of multicellular organismal process | 18 | 1286 | 9.90E−03 | ID3 ADRB2 ANGPT2 BMP4 ZC3H12A MAFB TWIST2 HGF NOTCH3 WNT11 ALOX12 ZBTB16 AVPR1A SOX11 NRARP CREB3L1 JUP GREM1 |
Regulation of protein phosphorylation | 20 | 1503 | 9.92E−03 | HGF BMP4 IL36G IL1RN MYOC FGF7 FGF18 ZC3H12A GREM1 ADRB2 ALOX12B WNT11 BDKRB1 SMPD3 CD36 ROR2 SH3RF3 TBX1 NGF S100A12 |
Cell surface receptor signaling pathway | 35 | 3287 | 1.00E−02 | HGF WNT11 BMP4 NGF IL36G IL1RN RSPO3 HEYL ROR2 NRARP JUP ANGPT2 DUOX1 CREB3L1 GREM1 CCBE1 FAM83G MYOC NOTCH3 CHRNA4 SMPD3 DLX5 GLP1R SDC1 RASL11B CD36 FGF7 FGF18 ZC3H12A ADRB2 SOX11 MDFI CHN1 CDA ELF3 |
Positive regulation of phosphorus metabolic process | 17 | 1183 | 1.00E−02 | HGF BMP4 IL36G IL1RN FGF7 FGF18 ZC3H12A ADRB2 ALOX12B WNT11 CD36 GREM1 ROR2 SH3RF3 TBX1 NGF S100A12 |
Positive regulation of phosphate metabolic process | 17 | 1183 | 1.00E−02 | HGF BMP4 IL36G IL1RN FGF7 FGF18 ZC3H12A ADRB2 ALOX12B WNT11 CD36 GREM1 ROR2 SH3RF3 TBX1 NGF S100A12 |
Cellular response to oxidised low-density lipoprotein particle stimulus | 2 | 10 | 1.05E−02 | SMPD3 CD36 |
Positive regulation of keratinocyte proliferation | 2 | 10 | 1.05E−02 | FGF7 TGM1 |
Positive regulation of mitochondrial depolarization | 2 | 10 | 1.05E−02 | MYOC ALOX12 |
Epithelial cell proliferation involved in lung morphogenesis | 2 | 10 | 1.05E−02 | BMP4 FGF7 |
Epithelial tube morphogenesis | 8 | 344 | 1.06E−02 | NRARP BMP4 ALOX12 GREB1L GREM1 SIX2 SOX11 WNT11 |
Epithelial to mesenchymal transition | 5 | 135 | 1.08E−02 | WNT11 BMP4 HEYL GREM1 HGF |
Negative regulation of growth | 7 | 269 | 1.08E−02 | BMP4 CDA BDKRB1 CD36 GREM1 ADRB2 WNT11 |
Mesoderm development | 5 | 136 | 1.11E−02 | BMP4 WNT11 SIX2 OVOL1 TBX1 |
Canonical Wnt signaling pathway | 8 | 350 | 1.16E−02 | RSPO3 NRARP JUP GREM1 WNT11 DLX5 SDC1 ROR2 |
Digestive tract development | 5 | 139 | 1.21E−02 | BMP4 PKDCC SIX2 SOX11 WNT11 |
Mesenchymal cell development | 4 | 84 | 1.23E−02 | BMP4 HEYL SOX11 TBX1 |
Positive regulation of bone mineralization | 3 | 40 | 1.24E−02 | BMP4 PKDCC ADRB2 |
Embryonic digestive tract development | 3 | 40 | 1.24E−02 | PKDCC SIX2 SOX11 |
Regulation of cellular response to growth factor stimulus | 7 | 277 | 1.24E−02 | FGF18 CREB3L1 GREM1 CCBE1 BMP4 RASL11B SOX11 |
Cell fate commitment | 7 | 277 | 1.24E−02 | WNT11 BMP4 PITX1 NOTCH3 ROR2 SIX2 TBX1 |
Glycoprotein biosynthetic process | 8 | 357 | 1.28E−02 | HS3ST3A1 B3GNT4 FUT2 B3GNT8 B3GNT3 CHST8 ST8SIA2 ST6GAL2 |
Transmembrane receptor protein serine/threonine kinase signaling pathway | 8 | 358 | 1.30E−02 | BMP4 GREM1 FAM83G SMPD3 DLX5 RASL11B ROR2 SOX11 |
Axis specification | 4 | 86 | 1.30E−02 | BMP4 SIX2 NRARP MDFI |
Negative regulation of T cell differentiation | 3 | 41 | 1.30E−02 | ZC3H12A NRARP BMP4 |
Positive regulation of nitrogen compound metabolic process | 35 | 3351 | 1.30E−02 | HGF DLX5 ZBTB16 BMP4 IL36G IL1RN HEYL JUP SOX11 FGF7 FGF18 S100A9 ELF3 ZC3H12A GREM1 ADRB2 ALOX12B CCBE1 PITX1 NOTCH3 WNT11 ALOX12 KRT17 CD36 CREB3L1 ROR2 SIX2 OVOL1 MAFB SH3RF3 GLIS3 TBX1 SMPD3 NGF S100A12 |
Metanephric nephron development | 3 | 41 | 1.30E−02 | BMP4 GREM1 SIX2 |
Negative regulation of cell communication | 19 | 1440 | 1.31E−02 | SIK1 NRARP HGF MYOC BMP4 KLK14 IL1RN CREB3L1 HEYL GREM1 ADRB2 FAM3D WNT11 RASL11B ZC3H12A AVPR1A ROR2 MDFI NOTCH3 |
Positive regulation of cellular metabolic process | 36 | 3482 | 1.31E−02 | HGF DLX5 ZBTB16 BMP4 IL36G IL1RN HEYL JUP SOX11 FGF7 FGF18 S100A9 ELF3 ZC3H12A GREM1 ADRB2 ALOX12B CCBE1 PITX1 NOTCH3 WNT11 ALOX12 KRT17 CD36 CREB3L1 AVPR1A ROR2 SIX2 OVOL1 MAFB SH3RF3 GLIS3 TBX1 SMPD3 NGF S100A12 |
Negative regulation of signaling | 19 | 1444 | 1.35E−02 | SIK1 NRARP HGF MYOC BMP4 KLK14 IL1RN CREB3L1 HEYL GREM1 ADRB2 FAM3D WNT11 RASL11B ZC3H12A AVPR1A ROR2 MDFI NOTCH3 |
Antimicrobial humoral response | 5 | 145 | 1.38E−02 | SLPI S100A9 S100A12 DEFB4A PI3 |
Hair follicle development | 4 | 88 | 1.38E−02 | KRT17 FGF7 TMEM79 KRT25 |
Regulation of epidermis development | 4 | 88 | 1.38E−02 | BMP4 KRT17 TMEM79 SULT2B1 |
Artery development | 4 | 88 | 1.38E−02 | BMP4 NOTCH3 WNT11 TBX1 |
Positive regulation of cell proliferation | 15 | 1022 | 1.39E−02 | NRARP BMP4 FGF7 GREM1 NOTCH3 SMPD3 DLX5 ALOX12 FGF18 AVPR1A SIX2 SOX11 TGM1 TBX1 ADRA1D |
Positive regulation of response to stimulus | 29 | 2621 | 1.39E−02 | BMP4 IL36G IL1RN RSPO3 NRARP JUP HGF MYOC KLK14 FGF18 S100A9 S100A12 ZC3H12A ADRB2 ALOX12B CCBE1 DLX5 CHN1 CD36 GREM1 ROR2 SOX11 DUOX1 WNT11 SH3RF3 NGF TBX1 FGF7 ELF3 |
Positive regulation of RNA metabolic process | 22 | 1789 | 1.39E−02 | DLX5 ZBTB16 HEYL JUP SOX11 BMP4 ELF3 ZC3H12A PITX1 NOTCH3 FGF7 CREB3L1 GREM1 ROR2 ADRB2 SIX2 OVOL1 MAFB WNT11 GLIS3 TBX1 HGF |
Positive regulation of membrane depolarization | 2 | 12 | 1.39E−02 | MYOC ALOX12 |
Regulation of intracellular signal transduction | 24 | 2027 | 1.42E−02 | BMP4 IL36G IL1RN SIK1 HGF MYOC FGF18 S100A9 S100A12 ZC3H12A ADRB2 ALOX12B CHN1 CD36 CREB3L1 GREM1 ROR2 SOX11 WNT11 SH3RF3 NGF TBX1 FGF7 RHOD |
Positive regulation of cellular protein metabolic process | 21 | 1680 | 1.42E−02 | HGF BMP4 IL36G IL1RN FGF7 FGF18 S100A9 ZC3H12A ADRB2 ALOX12B CCBE1 WNT11 ALOX12 KRT17 CD36 GREM1 ROR2 SH3RF3 TBX1 NGF S100A12 |
Lung alveolus development | 3 | 43 | 1.42E−02 | BMP4 SMPD3 PKDCC |
Pattern specification process | 9 | 451 | 1.42E−02 | BMP4 ZBTB16 GREM1 ROR2 SIX2 NRARP MAFB MDFI TBX1 |
Growth | 15 | 1028 | 1.44E−02 | NGF BMP4 FGF7 CDA WNT11 BDKRB1 SMPD3 KRT17 CD36 CYP19A1 PKDCC AVPR1A GREM1 ADRB2 S100A9 |
Molting cycle process | 4 | 90 | 1.44E−02 | KRT17 FGF7 TMEM79 KRT25 |
Hair cycle process | 4 | 90 | 1.44E−02 | KRT17 FGF7 TMEM79 KRT25 |
Wnt signaling pathway | 10 | 543 | 1.48E−02 | WNT11 RSPO3 NRARP JUP GREM1 DLX5 SDC1 ROR2 MYOC MDFI |
Negative regulation of osteoblast differentiation | 3 | 44 | 1.49E−02 | TWIST2 ID3 GREM1 |
Skin epidermis development | 4 | 91 | 1.49E−02 | KRT17 FGF7 TMEM79 KRT25 |
Regulation of Wnt signaling pathway | 8 | 371 | 1.49E−02 | RSPO3 NRARP JUP GREM1 WNT11 DLX5 ROR2 MDFI |
Cell–cell signaling by wnt | 10 | 545 | 1.50E−02 | WNT11 RSPO3 NRARP JUP GREM1 DLX5 SDC1 ROR2 MYOC MDFI |
Digestive system development | 5 | 151 | 1.54E−02 | BMP4 PKDCC SIX2 SOX11 WNT11 |
Insemination | 2 | 13 | 1.57E−02 | KLK14 AVPR1A |
Extracellular structure organization | 9 | 460 | 1.57E−02 | COL8A1 COL28A1 SMPD3 CD36 ADAMTSL4 ELF3 SDC1 GREM1 CREB3L1 |
Protein import into nucleus | 5 | 152 | 1.57E−02 | BMP4 ZC3H12A JUP CD36 SIX2 |
Positive regulation of cell death | 12 | 741 | 1.61E−02 | BMP4 ADAMTSL4 S100A9 ZC3H12A WNT11 ALOX12 ZBTB16 ID3 CD36 SIK1 PNMA5 NGF |
Muscle structure development | 11 | 645 | 1.61E−02 | BMP4 USP2 PITX1 SDC1 ID3 HEYL AVPR1A GREM1 SOX11 SIK1 TBX1 |
Anterior/posterior pattern specification | 6 | 222 | 1.63E−02 | BMP4 ZBTB16 ROR2 SIX2 NRARP TBX1 |
Epithelial cell differentiation involved in kidney development | 3 | 46 | 1.63E−02 | BMP4 GREM1 SIX2 |
Regulation of canonical Wnt signaling pathway | 7 | 298 | 1.65E−02 | RSPO3 NRARP JUP GREM1 WNT11 DLX5 ROR2 |
Regulation of blood vessel endothelial cell migration | 4 | 95 | 1.68E−02 | ANGPT2 ALOX12 FGF18 JUP |
Secretion by cell | 21 | 1715 | 1.70E−02 | CYP19A1 FGF7 FAM3D CHRNA4 SMPD3 CD36 IL1RN TMEM79 ZC3H12A AVPR1A SOX11 SDC1 G6PC2 CREB3L1 HGF GLP1R SLPI CDA S100A9 S100A12 JUP |
Gland development | 9 | 468 | 1.71E−02 | HGF PITX1 BMP4 CYP19A1 FGF7 ELF3 MAFB WNT11 TBX1 |
Embryonic cranial skeleton morphogenesis | 3 | 47 | 1.71E−02 | BMP4 SIX2 TBX1 |
Regulation of biomineral tissue development | 4 | 97 | 1.78E−02 | BMP4 PKDCC ADRB2 GREM1 |
Mating | 3 | 48 | 1.80E−02 | KLK14 PI3 AVPR1A |
Response to external stimulus | 28 | 2561 | 1.80E−02 | IL36G IL1RN SIK1 DEFB4A HGF ANGPT2 SLPI CD36 FGF7 FGF18 S100A9 S100A12 ZC3H12A JUP AJAP1 USP2 WNT11 BDKRB1 DLX5 ALOX12 BMP4 CHN1 CYP19A1 AVPR1A GREM1 ADRB2 PI3 LTB4R2 |
Positive regulation of canonical Wnt signaling pathway | 5 | 159 | 1.83E−02 | RSPO3 NRARP JUP DLX5 ROR2 |
Positive regulation of protein modification process | 17 | 1279 | 1.83E−02 | HGF BMP4 IL36G IL1RN FGF7 FGF18 ZC3H12A ADRB2 ALOX12B WNT11 CD36 GREM1 ROR2 SH3RF3 TBX1 NGF S100A12 |
Somite development | 4 | 98 | 1.83E−02 | WNT11 ROR2 SOX11 NRARP |
Regulation of binding | 8 | 388 | 1.83E−02 | ID3 SLPI BMP4 ADRB2 SOX11 CD36 MDFI NGF |
Genitalia development | 3 | 49 | 1.87E−02 | CYP19A1 GREB1L ROR2 |
Positive regulation of biomineral tissue development | 3 | 49 | 1.87E−02 | BMP4 PKDCC ADRB2 |
Ear development | 6 | 232 | 1.93E−02 | DLX5 BMP4 ROR2 SIX2 MAFB TBX1 |
Branching morphogenesis of an epithelial tube | 5 | 162 | 1.94E−02 | NRARP BMP4 GREB1L GREM1 SIX2 |
Positive regulation of exosomal secretion | 2 | 15 | 1.95E−02 | SDC1 SMPD3 |
Regulation of transcription by RNA polymerase II | 30 | 2830 | 1.95E−02 | DLX5 ZBTB16 BMP4 ELF3 HEYL JUP SOX11 ZC3H12A GREM1 FAM83G PITX1 NOTCH3 SMPD3 GLIS3 ID3 TBX4 CD36 CREB3L1 ROR2 ADRB2 SIX2 OVOL1 ZNF154 NRARP MAFB ZNF469 USP2 MDFI TBX1 HGF |
Activation of transmembrane receptor protein tyrosine kinase activity | 2 | 15 | 1.95E−02 | GREM1 ADRB2 |
Positive regulation of macromolecule biosynthetic process | 23 | 1978 | 1.96E−02 | DLX5 ZBTB16 HEYL JUP SOX11 HGF BMP4 ELF3 ZC3H12A GREM1 PITX1 NOTCH3 KRT17 FGF7 CREB3L1 ROR2 ADRB2 SIX2 OVOL1 MAFB WNT11 GLIS3 TBX1 |
Secretion | 22 | 1861 | 1.96E−02 | CYP19A1 FGF7 FAM3D CHRNA4 SMPD3 CD36 IL1RN TMEM79 ZC3H12A AVPR1A SOX11 SDC1 G6PC2 ALOX12B CREB3L1 HGF GLP1R SLPI CDA S100A9 S100A12 JUP |
Positive regulation of smooth muscle cell proliferation | 4 | 101 | 1.97E−02 | BMP4 NOTCH3 SMPD3 ALOX12 |
Negative regulation of hemopoiesis | 5 | 164 | 2.00E−02 | MAFB ZBTB16 ZC3H12A NRARP BMP4 |
Regulation of interleukin-6 production | 5 | 164 | 2.00E−02 | IL36G IL1RN ZC3H12A HGF CD36 |
Response to organic cyclic compound | 14 | 975 | 2.02E−02 | IL1RN DUOX1 HEYL JUP ANGPT2 SLC8A3 SDC1 ID3 CD36 ZC3H12A AVPR1A CLDN4 BMP4 CATSPERB |
Intermediate filament cytoskeleton organization | 3 | 51 | 2.02E−02 | TCHH KRT17 KRT25 |
Negative regulation of lymphocyte differentiation | 3 | 51 | 2.02E−02 | ZC3H12A NRARP BMP4 |
Negative regulation of cell differentiation | 12 | 774 | 2.08E−02 | ID3 BMP4 MAFB TWIST2 NOTCH3 ZBTB16 ZC3H12A SIX2 SOX11 NRARP GREM1 TBX1 |
Regulation of signaling receptor activity | 11 | 676 | 2.08E−02 | LYNX1 HGF BMP4 NGF IL36G IL1RN FGF7 FGF18 GREM1 FAM3D ADRB2 |
Negative regulation of transcription by RNA polymerase II | 13 | 876 | 2.08E−02 | BMP4 SOX11 ZBTB16 NOTCH3 ID3 CD36 CREB3L1 HEYL OVOL1 NRARP USP2 GLIS3 MDFI |
Anterior/posterior axis specification | 3 | 52 | 2.10E−02 | BMP4 SIX2 NRARP |
Positive regulation of cell–matrix adhesion | 3 | 52 | 2.10E−02 | MYOC CD36 JUP |
Intermediate filament-based process | 3 | 52 | 2.10E−02 | TCHH KRT17 KRT25 |
Regulation of transcription from RNA polymerase II promoter involved in heart development | 2 | 16 | 2.11E−02 | BMP4 GREM1 |
Regulation of exosomal secretion | 2 | 16 | 2.11E−02 | SDC1 SMPD3 |
Cellular response to oxygen-containing compound | 16 | 1199 | 2.13E−02 | IL36G IL1RN HGF ZC3H12A JUP SLC8A3 CHRNA4 SMPD3 GLP1R ID3 CD36 AVPR1A ADRB2 WNT11 TBX1 GNA15 |
Positive regulation of apoptotic process | 11 | 680 | 2.13E−02 | BMP4 ADAMTSL4 S100A9 WNT11 ALOX12 ZBTB16 ID3 ZC3H12A SIK1 PNMA5 NGF |
Negative regulation of response to stimulus | 21 | 1764 | 2.13E−02 | SIK1 NRARP HGF MYOC ANGPT2 BMP4 KLK14 IL1RN CREB3L1 HEYL GREM1 ADRB2 AJAP1 WNT11 ALOX12 RASL11B CYP19A1 ZC3H12A ROR2 MDFI NOTCH3 |
Negative regulation of binding | 5 | 168 | 2.13E−02 | ID3 SLPI ADRB2 SOX11 MDFI |
Positive regulation of macromolecule metabolic process | 35 | 3498 | 2.13E−02 | HGF DLX5 ZBTB16 BMP4 IL36G IL1RN HEYL JUP SOX11 FGF7 FGF18 S100A9 ELF3 ZC3H12A GREM1 ADRB2 ALOX12B CCBE1 PITX1 NOTCH3 WNT11 ALOX12 KRT17 CD36 CREB3L1 ROR2 SIX2 OVOL1 MAFB NGF SH3RF3 GLIS3 ACTG2 TBX1 S100A12 |
Muscle organ development | 8 | 404 | 2.15E−02 | BMP4 USP2 PITX1 ID3 HEYL GREM1 SOX11 TBX1 |
Negative regulation of DNA binding | 3 | 53 | 2.16E−02 | ID3 SOX11 MDFI |
Mesenchyme morphogenesis | 3 | 53 | 2.16E−02 | WNT11 HEYL ACTG2 |
Regulation of phosphorylation | 20 | 1653 | 2.17E−02 | HGF BMP4 IL36G IL1RN MYOC FGF7 FGF18 ZC3H12A GREM1 ADRB2 ALOX12B WNT11 BDKRB1 SMPD3 CD36 ROR2 SH3RF3 TBX1 NGF S100A12 |
Positive regulation of programmed cell death | 11 | 686 | 2.23E−02 | BMP4 ADAMTSL4 S100A9 WNT11 ALOX12 ZBTB16 ID3 ZC3H12A SIK1 PNMA5 NGF |
Unsaturated fatty acid biosynthetic process | 3 | 54 | 2.25E−02 | ALOX12 AVPR1A ALOX12B |
Inner ear morphogenesis | 4 | 107 | 2.25E−02 | DLX5 ROR2 MAFB TBX1 |
Regulation of striated muscle cell differentiation | 4 | 107 | 2.25E−02 | GREM1 BMP4 SIK1 TBX1 |
Negative regulation of signal transduction | 17 | 1321 | 2.27E−02 | SIK1 NRARP HGF MYOC BMP4 KLK14 IL1RN CREB3L1 HEYL GREM1 ADRB2 WNT11 RASL11B ZC3H12A ROR2 MDFI NOTCH3 |
Lipoxygenase pathway | 2 | 17 | 2.27E−02 | ALOX12 ALOX12B |
Interleukin-6 production | 5 | 172 | 2.27E−02 | IL36G IL1RN ZC3H12A HGF CD36 |
Linoleic acid metabolic process | 2 | 17 | 2.27E−02 | ALOX12 ALOX12B |
Pulmonary valve morphogenesis | 2 | 17 | 2.27E−02 | BMP4 HEYL |
Negative regulation of molecular function | 16 | 1216 | 2.33E−02 | ID3 HGF SLPI BMP4 ZC3H12A HEYL ADRB2 PI3 NGF SOX11 LYNX1 SPINK9 COL28A1 MDFI SIK1 LTB4R2 |
Positive regulation of metabolic process | 37 | 3789 | 2.34E−02 | HGF DLX5 ZBTB16 BMP4 IL36G IL1RN HEYL JUP SOX11 FGF7 FGF18 CREB3L1 S100A9 ELF3 ZC3H12A GREM1 ADRB2 ALOX12B CCBE1 PITX1 NOTCH3 WNT11 ALOX12 KRT17 CD36 AVPR1A ROR2 SIX2 OVOL1 MAFB NGF SH3RF3 GLIS3 ACTG2 TBX1 SMPD3 S100A12 |
Segmentation | 4 | 109 | 2.35E−02 | BMP4 ROR2 NRARP MAFB |
Regulation of stress-activated MAPK cascade | 6 | 248 | 2.38E−02 | IL36G IL1RN ZC3H12A HGF ROR2 SH3RF3 |
Cell differentiation involved in kidney development | 3 | 56 | 2.42E−02 | BMP4 GREM1 SIX2 |
Regulation of epithelial cell proliferation | 7 | 330 | 2.43E−02 | NRARP BMP4 FGF7 DLX5 SOX11 TGM1 TBX1 |
Import into nucleus | 5 | 176 | 2.44E−02 | BMP4 ZC3H12A JUP CD36 SIX2 |
Regulation of stress-activated protein kinase signaling cascade | 6 | 250 | 2.44E−02 | IL36G IL1RN ZC3H12A HGF ROR2 SH3RF3 |
Positive regulation of protein metabolic process | 21 | 1796 | 2.45E−02 | HGF BMP4 IL36G IL1RN FGF7 FGF18 S100A9 ZC3H12A ADRB2 ALOX12B CCBE1 WNT11 ALOX12 KRT17 CD36 GREM1 ROR2 SH3RF3 TBX1 NGF S100A12 |
Carbohydrate derivative biosynthetic process | 12 | 800 | 2.45E−02 | HS3ST3A1 B3GNT4 FUT2 B3GNT8 B3GNT3 PAPSS2 CHST8 ST8SIA2 SMPD3 ST6GAL2 SDC1 CDA |
Regulation of nucleocytoplasmic transport | 4 | 111 | 2.46E−02 | BMP4 ZC3H12A JUP CD36 |
Embryonic digestive tract morphogenesis | 2 | 18 | 2.47E−02 | SIX2 SOX11 |
Regulation of kidney development | 3 | 57 | 2.49E−02 | BMP4 GREM1 SIX2 |
Negative regulation of leukocyte differentiation | 4 | 112 | 2.52E−02 | ZC3H12A NRARP MAFB BMP4 |
Lung morphogenesis | 3 | 58 | 2.60E−02 | BMP4 FGF7 SOX11 |
Leukocyte chemotaxis | 6 | 255 | 2.62E−02 | IL36G IL1RN S100A9 CYP19A1 GREM1 S100A12 |
Cell junction assembly | 6 | 255 | 2.62E−02 | MYOC JUP WNT11 GREM1 RHOD FBLIM1 |
Mucopolysaccharide metabolic process | 4 | 114 | 2.65E−02 | HGF SMPD3 B3GNT4 B3GNT3 |
Regulation of growth | 11 | 710 | 2.67E−02 | NGF BMP4 CDA BDKRB1 KRT17 CD36 AVPR1A GREM1 ADRB2 WNT11 S100A9 |
Regulation of production of miRNAs involved in gene silencing by miRNA | 2 | 19 | 2.68E−02 | BMP4 ZC3H12A |
Exosomal secretion | 2 | 19 | 2.68E−02 | SDC1 SMPD3 |
Keratinocyte migration | 2 | 19 | 2.68E−02 | FGF7 LTB4R2 |
Kidney mesenchyme development | 2 | 19 | 2.68E−02 | BMP4 SIX2 |
Negative regulation of DNA-binding transcription factor activity | 5 | 182 | 2.69E−02 | ID3 ZC3H12A HEYL SIK1 MDFI |
Bone morphogenesis | 4 | 115 | 2.69E−02 | SMPD3 DLX5 BMP4 FGF18 |
Polysaccharide metabolic process | 4 | 116 | 2.76E−02 | B3GNT4 B3GNT8 B3GNT3 SMPD3 |
Cellular oxidant detoxification | 4 | 117 | 2.83E−02 | CD36 DUOX1 S100A9 GPX3 |
Molting cycle | 4 | 117 | 2.83E−02 | KRT25 KRT17 FGF7 TMEM79 |
Hair cycle | 4 | 117 | 2.83E−02 | KRT25 KRT17 FGF7 TMEM79 |
Extracellular exosome biogenesis | 2 | 20 | 2.84E−02 | SDC1 SMPD3 |
Positive regulation of cardiac muscle cell differentiation | 2 | 20 | 2.84E−02 | GREM1 BMP4 |
Regulation of cell growth | 8 | 432 | 2.84E−02 | NGF CDA BDKRB1 KRT17 AVPR1A GREM1 WNT11 S100A9 |
Glycoprotein metabolic process | 8 | 432 | 2.84E−02 | HS3ST3A1 B3GNT4 FUT2 B3GNT8 B3GNT3 CHST8 ST8SIA2 ST6GAL2 |
Notochord development | 2 | 20 | 2.84E−02 | WNT11 ID3 |
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis | 2 | 20 | 2.84E−02 | NRARP BMP4 |
Positive regulation of stress-activated MAPK cascade | 5 | 186 | 2.84E−02 | IL36G IL1RN ZC3H12A ROR2 SH3RF3 |
Response to hydroperoxide | 2 | 20 | 2.84E−02 | CD36 GPX3 |
Middle ear morphogenesis | 2 | 20 | 2.84E−02 | SIX2 TBX1 |
Entrainment of circadian clock by photoperiod | 2 | 20 | 2.84E−02 | USP2 SIK1 |
Negative regulation of leukocyte chemotaxis | 2 | 20 | 2.84E−02 | CYP19A1 GREM1 |
Regulation of production of small RNA involved in gene silencing by RNA | 2 | 20 | 2.84E−02 | BMP4 ZC3H12A |
Hormone secretion | 7 | 346 | 2.86E−02 | CYP19A1 FAM3D SMPD3 IL1RN SOX11 G6PC2 GLP1R |
Positive regulation of stress-activated protein kinase signaling cascade | 5 | 187 | 2.88E−02 | IL36G IL1RN ZC3H12A ROR2 SH3RF3 |
Negative regulation of endopeptidase activity | 6 | 264 | 2.89E−02 | HGF PI3 SLPI SPINK9 COL28A1 NGF |
Neutrophil chemotaxis | 4 | 119 | 2.89E−02 | IL36G IL1RN S100A9 S100A12 |
Embryonic digit morphogenesis | 3 | 62 | 2.91E−02 | ZBTB16 BMP4 ROR2 |
Modification of morphology or physiology of other organism | 5 | 188 | 2.91E−02 | SLPI S100A9 S100A12 ZC3H12A DEFB4A |
Positive regulation of cell-substrate adhesion | 4 | 120 | 2.95E−02 | MYOC CD36 COL8A1 JUP |
Positive regulation of protein serine/threonine kinase activity | 7 | 349 | 2.95E−02 | BMP4 FGF18 HGF ROR2 ADRB2 NGF S100A12 |
Regulation of cell-substrate junction assembly | 3 | 63 | 3.00E−02 | MYOC GREM1 RHOD |
Sialylation | 2 | 21 | 3.00E−02 | ST8SIA2 ST6GAL2 |
Regulation of protein localization to nucleus | 4 | 121 | 3.00E−02 | BMP4 ZC3H12A JUP CD36 |
Protein glycosylation | 6 | 268 | 3.00E−02 | B3GNT4 FUT2 B3GNT8 B3GNT3 ST8SIA2 ST6GAL2 |
Positive regulation of Wnt signaling pathway | 5 | 190 | 3.00E−02 | RSPO3 NRARP JUP DLX5 ROR2 |
Negative regulation of chondrocyte differentiation | 2 | 21 | 3.00E−02 | BMP4 GREM1 |
Macromolecule glycosylation | 6 | 268 | 3.00E−02 | B3GNT4 FUT2 B3GNT8 B3GNT3 ST8SIA2 ST6GAL2 |
Regulation of focal adhesion assembly | 3 | 63 | 3.00E−02 | MYOC GREM1 RHOD |
Regulation of mitochondrial depolarization | 2 | 21 | 3.00E−02 | MYOC ALOX12 |
Pulmonary valve development | 2 | 21 | 3.00E−02 | BMP4 HEYL |
Chordate embryonic development | 10 | 632 | 3.02E−02 | MDFI BMP4 RSPO3 ELF3 ROR2 SIX2 SOX11 NRARP WNT11 TBX1 |
O-glycan processing | 3 | 64 | 3.07E−02 | B3GNT4 B3GNT8 B3GNT3 |
Respiratory gaseous exchange | 3 | 65 | 3.18E−02 | CHRNA4 CCBE1 MAFB |
Gland morphogenesis | 4 | 124 | 3.18E−02 | HGF BMP4 FGF7 ELF3 |
Negative regulation of chemotaxis | 3 | 65 | 3.18E−02 | ANGPT2 CYP19A1 GREM1 |
Positive regulation of striated muscle cell differentiation | 3 | 65 | 3.18E−02 | GREM1 BMP4 TBX1 |
Hormone transport | 7 | 357 | 3.19E−02 | CYP19A1 FAM3D SMPD3 IL1RN SOX11 G6PC2 GLP1R |
Extracellular vesicle biogenesis | 2 | 22 | 3.21E−02 | SDC1 SMPD3 |
Positive regulation of transcription of Notch receptor target | 2 | 22 | 3.21E−02 | NOTCH3 HEYL |
Gastrulation | 5 | 195 | 3.21E−02 | BMP4 IL1RN WNT11 SIX2 COL8A1 |
Negative regulation of peptidase activity | 6 | 273 | 3.21E−02 | HGF PI3 SLPI NGF SPINK9 COL28A1 |
Negative regulation of response to external stimulus | 7 | 358 | 3.21E−02 | ANGPT2 AJAP1 HGF ALOX12 CYP19A1 ZC3H12A GREM1 |
Proteolysis | 22 | 1988 | 3.24E−02 | CPXM2 HGF USP2 KLK14 S100A9 ZC3H12A CCBE1 KLK12 PRSS50 ALOX12 PI3 SLPI KLK10 NGF ADAMTSL4 PRSS35 ADAMTS15 KLK13 PRSS27 SPINK9 COL28A1 ADRB2 |
Negative regulation of cell-substrate adhesion | 3 | 66 | 3.25E−02 | MYOC AJAP1 ANGPT2 |
Transcription by RNA polymerase II | 30 | 2992 | 3.25E−02 | DLX5 ZBTB16 BMP4 ELF3 HEYL JUP SOX11 ZC3H12A GREM1 FAM83G PITX1 NOTCH3 SMPD3 GLIS3 ID3 TBX4 CD36 CREB3L1 ROR2 ADRB2 SIX2 OVOL1 ZNF154 NRARP MAFB ZNF469 USP2 MDFI TBX1 HGF |
Regulation of phosphate metabolic process | 21 | 1870 | 3.25E−02 | HGF BMP4 IL36G IL1RN MYOC FGF7 FGF18 CDA ZC3H12A GREM1 ADRB2 ALOX12B WNT11 BDKRB1 SMPD3 CD36 ROR2 SH3RF3 TBX1 NGF S100A12 |
Regulation of membrane potential | 8 | 450 | 3.25E−02 | CHRNA4 KCNK12 MYOC SLC8A3 ALOX12 CD36 ADRB2 JUP |
Positive regulation of MAP kinase activity | 6 | 275 | 3.25E−02 | BMP4 FGF18 HGF ROR2 NGF S100A12 |
Cellular detoxification | 4 | 126 | 3.26E−02 | CD36 DUOX1 S100A9 GPX3 |
Carbohydrate metabolic process | 10 | 644 | 3.27E−02 | G6PC2 B3GNT4 B3GNT8 B3GNT3 ST8SIA2 ST6GAL2 SMPD3 CHST8 FUT2 SIK1 |
Positive regulation of nucleobase-containing compound metabolic process | 22 | 1993 | 3.27E−02 | DLX5 ZBTB16 HEYL JUP SOX11 HGF BMP4 ELF3 ZC3H12A GREM1 PITX1 NOTCH3 FGF7 CREB3L1 ROR2 ADRB2 SIX2 OVOL1 MAFB WNT11 GLIS3 TBX1 |
Regulation of phosphorus metabolic process | 21 | 1872 | 3.27E−02 | HGF BMP4 IL36G IL1RN MYOC FGF7 FGF18 CDA ZC3H12A GREM1 ADRB2 ALOX12B WNT11 BDKRB1 SMPD3 CD36 ROR2 SH3RF3 TBX1 NGF S100A12 |
Protein localization to nucleus | 6 | 276 | 3.27E−02 | BMP4 ZC3H12A JUP ZBTB16 CD36 SIX2 |
Cofactor catabolic process | 3 | 67 | 3.31E−02 | GPX3 DUOX1 ALDH1L1 |
Male genitalia development | 2 | 23 | 3.35E−02 | GREB1L ROR2 |
Lens morphogenesis in camera-type eye | 2 | 23 | 3.35E−02 | BMP4 SOX11 |
Positive regulation of epidermal cell differentiation | 2 | 23 | 3.35E−02 | BMP4 SULT2B1 |
Negative regulation of muscle contraction | 2 | 23 | 3.35E−02 | ADRB2 ZC3H12A |
Branching involved in salivary gland morphogenesis | 2 | 23 | 3.35E−02 | HGF FGF7 |
Endothelial tube morphogenesis | 2 | 23 | 3.35E−02 | BMP4 ALOX12 |
Morphogenesis of an endothelium | 2 | 23 | 3.35E−02 | BMP4 ALOX12 |
Cranial skeletal system development | 3 | 68 | 3.39E−02 | BMP4 SIX2 TBX1 |
Inflammatory response | 12 | 856 | 3.39E−02 | BDKRB1 LTB4R2 S100A9 HGF SDC1 IL36G IL1RN CYP19A1 S100A12 ELF3 ZC3H12A CD36 |
Negative regulation of cell–cell adhesion | 5 | 200 | 3.39E−02 | IL1RN ALOX12 ZC3H12A NRARP BMP4 |
Glycosylation | 6 | 280 | 3.41E−02 | B3GNT4 FUT2 B3GNT8 B3GNT3 ST8SIA2 ST6GAL2 |
Embryo development ending in birth or egg hatching | 10 | 652 | 3.44E−02 | MDFI BMP4 RSPO3 ELF3 ROR2 SIX2 SOX11 NRARP WNT11 TBX1 |
Regulation of adherens junction organization | 3 | 69 | 3.48E−02 | MYOC GREM1 RHOD |
Skeletal muscle cell differentiation | 3 | 69 | 3.48E−02 | HEYL SOX11 TBX1 |
Ceramide biosynthetic process | 3 | 69 | 3.48E−02 | ST8SIA2 ALOX12B SMPD3 |
Response to toxic substance | 9 | 555 | 3.49E−02 | CHRNA4 HGF SMPD3 SDC1 CD36 DUOX1 S100A9 ZC3H12A GPX3 |
Photoperiodism | 2 | 24 | 3.51E−02 | USP2 SIK1 |
Positive regulation of lipid storage | 2 | 24 | 3.51E−02 | ZC3H12A CD36 |
Purine ribonucleoside bisphosphate metabolic process | 2 | 24 | 3.51E−02 | PAPSS2 SULT2B1 |
Myelination | 4 | 131 | 3.51E−02 | MALL HGF MYOC SLC8A3 |
Positive regulation of protein kinase activity | 9 | 557 | 3.51E−02 | BMP4 FGF18 HGF WNT11 GREM1 ROR2 ADRB2 NGF S100A12 |
3 -phosphoadenosine 5 -phosphosulfate metabolic process | 2 | 24 | 3.51E−02 | PAPSS2 SULT2B1 |
Mitochondrial depolarization | 2 | 24 | 3.51E−02 | MYOC ALOX12 |
Uterus development | 2 | 24 | 3.51E−02 | CYP19A1 GREB1L |
Regulation of cellular protein metabolic process | 28 | 2768 | 3.54E−02 | HGF BMP4 IL36G IL1RN MYOC FGF7 FGF18 S100A9 ZC3H12A GREM1 ADRB2 ALOX12B CCBE1 WNT11 BDKRB1 SMPD3 ALOX12 PI3 SLPI KRT17 NGF CD36 ROR2 SPINK9 COL28A1 SH3RF3 TBX1 S100A12 |
Formation of primary germ layer | 4 | 132 | 3.56E−02 | BMP4 WNT11 SIX2 COL8A1 |
Endocrine system development | 4 | 132 | 3.56E−02 | BMP4 PITX1 WNT11 TBX1 |
Regulation of DNA binding | 4 | 132 | 3.56E−02 | ID3 SOX11 MDFI NGF |
Striated muscle cell differentiation | 6 | 285 | 3.56E−02 | BMP4 AVPR1A GREM1 SDC1 SIK1 TBX1 |
Inner ear development | 5 | 205 | 3.59E−02 | DLX5 BMP4 ROR2 MAFB TBX1 |
Neutrophil migration | 4 | 133 | 3.62E−02 | IL36G IL1RN S100A9 S100A12 |