Fig. 8

Quantification of NFT pathology following human brain inoculation. Quantification of NFT burden (NFT count per region of interest) in AD- and Ctrl-inoculated lemurs. NFTs were detected in all of AD-inoculated animals and in none of Ctrl-inoculated lemurs. In AD-inoculated animals, NFT burden was increased at the level of the inoculation site, e.g. in the posterior cingulate cortex (a) and the parietal area 7 (b), as well as in juxtaposing regions, including the retrosplenial cortex (c), anterior cingulate cortex (d) and parietal area 5 (e). NFTs were also detected in the hippocampus (f) and in some regions more distant from the inoculation sites, including the temporal area 20 (g), frontal area 4 (h) and entorhinal cortex (i). No statistical difference was reported between AD1- and AD2-inoculated lemurs (p > 0.05; Mann–Whitney’s test). Data are shown as mean ± s.e.m