Fig. 2

Aβ pathology throughout the brains of mouse lemurs inoculated with AD brain extracts. Representative images of 4G8 immunolabelling showing Aβ pathology throughout the brains of mouse lemurs following AD brain extracts inoculations. Aβ deposition was observed in the inoculated posterior cingulate cortex (i) and around the needle tract in the parietal cortex (area 7; l-n, r). Adjacent regions including the retrosplenial cortex (q), parietal area 5 (j-k) and anterior cingulate cortex (a, e) also displayed Aβ pathology. Additionally, Aβ plaques were detected in the hippocampus (p, t) and other regions more distant from the inoculation sites including the superior temporal cortex (areas 22 and 21; g, o, s), the parietal areas 1–3 (c, f) and the frontal cortex (area 4; b). Occipital areas also displayed Aβ deposits (areas 17 and 18; u-x). The red crosses indicate the inoculated region. Scale bars: 500 µm in whole slice images, 100 µm in zooms and 20 µm in inserts