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Table 1 Details of transgenic mouse models and quantification of Aβ plaque pathology. n.d.-not detected, ROI-Region of interest

From: TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits

Sr. No. Transgenic mouse models Age (months) Sex Genotype No. of animals (n)   Total number of Aβ plaques/ROI stained with various antibodies
  Somatosensory cortex (SSC) Retrosplenial cortex (RSC) Dentate gyrus (DG)
  pSer8-Aβ N3p3-Aβ nmAβ Aβ (4G8) Aβ (2964) pSer8-Aβ N3p3-Aβ nmAβ Aβ (4G8) Aβ (2964) pSer8-Aβ N3p3-Aβ nmAβ Aβ (4G8) Aβ (2964)
1 5xFAD 5 M Male TREM2+/+ 5 Total plaque count/group 1117 1664 1791 1847 1842 1353 1770 1724 1777 1815 933 1263 1932 1872 1857
       Plaque load (%) 2.89 8.11 10.91 11.42 11.46 4.35 7.49 7.71 9.27 8.52 2.89 5.12 8.76 8.98 8.93
     TREM2−/− 5 Total plaque count/group 1631 1836 2247 2314 2305 1734 1899 2120 2169 2198 1257 1403 2258 2196 2183
       Plaque load (%) 9.53 10.80 17.90 19.08 17.49 7.66 9.29 13.82 14.41 14.45 5.27 6.94 13.55 14.29 14.22
   15 M Male TREM2+/+ 5 Total plaque count/group 1565 2322 3616 3725 3833 2057 2559 3641 3802 3778 1530 2535 3426 3537 3461
       Plaque load (%) 4.59 17.26 27.31 28.10 29.38 7.09 13.19 25.04 25.84 26.41 5.49 10.24 21.40 21.51 21.00
     TREM2−/− 5 Total plaque count/group 2250 3013 4414 4417 4523 2846 3285 4398 4520 4488 2153 3139 4033 4144 4096
       Plaque load (%) 13.06 23.76 41.46 41.37 42.44 15.73 21.93 32.66 35.63 33.95 10.99 16.07 32.16 32.39 31.95
2 APP/PS1L166P 4 M Male TREM2+/+ 5 Total plaque count/group 422 n.d. 1027 967 982 420 n.d. 852 892 917 245 n.d. 626 760 776
       Plaque load (%) 1.93 n.d. 5.51 4.96 5.25 2.46 n.d. 5.59 6.52 6.62 1.35 n.d. 4.14 5.03 4.63
     TREM2−/− 5 Total plaque count/group 607 n.d. 1215 1156 1193 631 n.d. 1062 1115 1132 446 n.d. 845 957 988
       Plaque load (%) 2.93 n.d. 8.19 9.03 9.88 4.09 n.d. 7.64 9.14 9.18 2.46 n.d. 6.57 7.01 7.63
   12 M Female TREM2+/+ 5 Total plaque count/group 804 1935 4003 4090 3959 942 2096 3776 4050 3943 649 1584 2437 2482 2485
       Plaque load (%) 4.81 14.99 28.03 27.91 26.88 6.57 15.42 30.03 32.66 32.23 3.83 9.56 17.92 17.82 15.41
     TREM2−/− 5 Total plaque count/group 1424 2545 4655 4770 4571 1391 2562 4226 4518 4398 972 1951 2766 2835 2835
       Plaque load (%) 9.94 21.24 39.43 41.24 40.67 13.65 21.88 47.34 47.87 47.04 7.12 12.86 24.29 22.81 25.31
3 APP/PS1ΔE9 12 M Female TREM2 3 Total plaque count/group 491 1068 2044 2233 2331 414 889 1489 1785 1685 183 548 717 874 965
       Plaque load (%) 4.09 12.58 30.05 30.40 35.16 3.21 11.29 21.13 24.68 23.77 1.87 6.58 9.13 12.23 13.03
     TREM2T66M 3 Total plaque count/group 757 1397 2570 2581 2605 735 1349 1975 2073 2060 255 770 1001 1119 1086
       Plaque load (%) 8.02 18.63 39.91 39.44 41.83 7.36 18.89 30.25 31.31 33.08 3.37 12.10 14.19 16.75 15.94