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Table 2 Relation of Lewy bodies with LATE-NC

From: The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons

Predictor Outcome: LATE-NC
Odds ratio (95% confidence intervals), p-value
Model 1 Model 2
Age-at-death 1.08 (1.06, 1.10), p < 0.001 1.09 (1.07, 1.11), p < 0.001
Male sex 0.89 (0.70, 1.14), p = 0.382 0.88 (0.68, 1.13), p = 0.334
Education 0.99 (0.96, 1.02), p = 0.755 0.98 (0.95, 1.02), p = 0.495
Nigral predominant-type LBs 0.78 (0.31, 1.91), p = 0.587 0.79 (0.32, 1.96), p = 0.621
Limbic-type LBs 1.01 (0.71, 1.45), p = 0.920 1.01 (0.70, 1.45), p = 0.953
Neocortical-type LBs 1.70 (1.26, 2.30), p < 0.001 1.72 (1.26, 2.34), p < 0.001
AD pathology 2.09 (1.76, 2.49), p < 0.001 1.85 (1.53, 2.22), p < 0.001
APOE ε4   1.83 (1.40, 2.37), p < 0.001
  1. Model 1 was adjusted for age-at-death, sex, education, and AD pathology
  2. Model 2 was adjusted for age-at-death, sex, education, AD pathology, and APOE ε4