The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons

Table 2 Relation of Lewy bodies with LATE-NC

Predictor	Outcome: LATE-NC Odds ratio (95% confidence intervals), p-value
Predictor	Model 1	Model 2
Age-at-death	1.08 (1.06, 1.10), p < 0.001	1.09 (1.07, 1.11), p < 0.001
Male sex	0.89 (0.70, 1.14), p = 0.382	0.88 (0.68, 1.13), p = 0.334
Education	0.99 (0.96, 1.02), p = 0.755	0.98 (0.95, 1.02), p = 0.495
Nigral predominant-type LBs	0.78 (0.31, 1.91), p = 0.587	0.79 (0.32, 1.96), p = 0.621
Limbic-type LBs	1.01 (0.71, 1.45), p = 0.920	1.01 (0.70, 1.45), p = 0.953
Neocortical-type LBs	1.70 (1.26, 2.30), p < 0.001	1.72 (1.26, 2.34), p < 0.001
AD pathology	2.09 (1.76, 2.49), p < 0.001	1.85 (1.53, 2.22), p < 0.001
APOE ε4		1.83 (1.40, 2.37), p < 0.001

Model 1 was adjusted for age-at-death, sex, education, and AD pathology
Model 2 was adjusted for age-at-death, sex, education, AD pathology, and APOE ε4

ISSN: 2051-5960