Fig. 3
From: Loss of presenilin function enhances tau phosphorylation and aggregation in mice
Absence of PS increases tau phosphorylation in memory-related brain regions. Left: Representative immunohistochemical images of phosphorylated Ser202 (CP13, left) and Ser396/404 (PHF-1, right) tau in 12 month-old control (WT) and PS cKO mice. Scale bar: 100 µm. Right: Quantitative analysis of total intensity and number of positive cells of CP13 (left) and PHF-1 (right) immunohistochemistry. Values represent mean ± s.e.m. (n = 3 slices/mice, 3 mice/group). Statistical analysis was determined by unpaired student’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001. Abbreviations: CA1/CA3 hippocampus; CC, corpus callosum; DG, dentate gyrus; EC, entorhinal cortex; RSC, restrosplenial cortex