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Table 3 Unexpected seeding results

From: Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns

Brain region Expectation Reference for expectation Findings
1-TRE Seeding in all cases Kaufmann et al. [28] Unexpected =  > n = 2/6 cases at NFT stage I did not show seeding
4-AMY Seeding starting at late NFT stages Braak et al. [4] Unexpected =  > seeding in n = 1/6 NFT stage I case, in n = 6/7 NFT stage III cases and in all NFT stage V cases
6-TTG Seeding starting at late NFT stages (V-VI) Braak et al. [4] Unexpected =  > seeding in n = 1/7 NFT stage III case; expectedly in n = 6/7 NFT stage V cases
12-GP Seeding not expected since it typically does not develop tau pathology (in contrast to Aβ plaques) in AD Braak and Del Tredic [6] Unexpected =  > seeding in n = 3/7 NFT stage III cases and in n = 6/7 NFT stage V cases
15-SN Seeding starting at late NFT stages (V-VI) Braak et al. [4] Unexpected =  > seeding seen earlier—in most NFT stage III cases (n = 6/7) and in all NFT stage V cases
18-PG Seeding not expected Braak et al. [4] Unexpected =  > seeding in n = 1/7 NFT stage III case and in n = 2/7 NFT stage V cases Note: The dorsal raphe nucleus (DRN) in case 7 was punched accidentally and likely explains the seeding in this sample
19-IO Seeding not expected Braak et al. [4] Unexpected =  > seeding in n = 2/7 NFT stage III cases and in n = 2/7 NFT stage V cases Note: Some punches from IO were contaminated by overlapping AT8-positive neurons/axons in the IRZ
20-CC Seeding not expected Braak et al. [4] Unexpected =  > seeding in n = 2/7 NFT stage III cases
21-DN Seeding not expected Braak et al. [4] Unexpected =  > seeding in n = 1/7 NFT stage III case and in n = 1/7 NFT stage V case
22-IC Seeding not expected Braak et al. [4] Unexpected =  > seeding in n = 1/7 NFT stage III case and in n = 4/7 NFT stage V cases
24-OB Seeding starting at early/intermediate NFT stages (II-III) Attems et al. [2] As expected, seeding in n = 4/7 NFT stage III cases; however, unexpected =  > in only n = 5/6 NFT stage V cases
25-OC Seeding expected DeVos et al. [14] Unexpected =  > seeding in only one individual (case 20)
  1. Summary of seeding results that were unexpected based on seeding results and/or neuropathology data from prior studies. For a complete list of all brain regions and expectations prior to the study refer to Additional file 1: Table S2. For unexpected results, AT8 IHC was performed as listed in Additional file 1: Table S1