Table 3 Unexpected seeding results
From: Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns
Brain region | Expectation | Reference for expectation | Findings |
|---|---|---|---|
1-TRE | Seeding in all cases | Kaufmann et al. [28] | Unexpected = > n = 2/6 cases at NFT stage I did not show seeding |
4-AMY | Seeding starting at late NFT stages | Braak et al. [4] | Unexpected = > seeding in n = 1/6 NFT stage I case, in n = 6/7 NFT stage III cases and in all NFT stage V cases |
6-TTG | Seeding starting at late NFT stages (V-VI) | Braak et al. [4] | Unexpected = > seeding in n = 1/7 NFT stage III case; expectedly in n = 6/7 NFT stage V cases |
12-GP | Seeding not expected since it typically does not develop tau pathology (in contrast to Aβ plaques) in AD | Braak and Del Tredic [6] | Unexpected = > seeding in n = 3/7 NFT stage III cases and in n = 6/7 NFT stage V cases |
15-SN | Seeding starting at late NFT stages (V-VI) | Braak et al. [4] | Unexpected = > seeding seen earlier—in most NFT stage III cases (n = 6/7) and in all NFT stage V cases |
18-PG | Seeding not expected | Braak et al. [4] | Unexpected = > seeding in n = 1/7 NFT stage III case and in n = 2/7 NFT stage V cases Note: The dorsal raphe nucleus (DRN) in case 7 was punched accidentally and likely explains the seeding in this sample |
19-IO | Seeding not expected | Braak et al. [4] | Unexpected = > seeding in n = 2/7 NFT stage III cases and in n = 2/7 NFT stage V cases Note: Some punches from IO were contaminated by overlapping AT8-positive neurons/axons in the IRZ |
20-CC | Seeding not expected | Braak et al. [4] | Unexpected = > seeding in n = 2/7 NFT stage III cases |
21-DN | Seeding not expected | Braak et al. [4] | Unexpected = > seeding in n = 1/7 NFT stage III case and in n = 1/7 NFT stage V case |
22-IC | Seeding not expected | Braak et al. [4] | Unexpected = > seeding in n = 1/7 NFT stage III case and in n = 4/7 NFT stage V cases |
24-OB | Seeding starting at early/intermediate NFT stages (II-III) | Attems et al. [2] | As expected, seeding in n = 4/7 NFT stage III cases; however, unexpected = > in only n = 5/6 NFT stage V cases |
25-OC | Seeding expected | DeVos et al. [14] | Unexpected = > seeding in only one individual (case 20) |