Fig. 4

A11-positive oligomers and high molecular weight (HMW) Aβ oligomers in the human brain extracts. A11-positive oligomers for the Patient 1–12 in the Table 1 were anlayzed by dot blot analyses (A). Quantification of densitometry showed that the value of A11-positive oligomers in Alzheimer’s disease (AD), cerebral amyloid angiopathy (CAA), and less Aβ groups were slightly lower than those of the AD + CAA group (B). Similarly, the concentrations of HMW Aβ oligomers in the AD + CAA group were slightly higher than those in the other three groups (C). The A11-positive oligomer ratio and HMW Aβ oligomer ratio in the less Aβ group were higher than those in the other three groups (D and E)