Fig. 8

AD-tau-injected 5XFAD × TREM2^+/− mice had greater Aβ plaque-associated microglia than 5XFAD × TREM2^−/− mice but comparable AT8-positive NP tau pathology a Representative images of cortical Aβ plaque-associated microglia in 5XFAD × TREM2^+/+ and 5XFAD × TREM2^−/− mice. b Quantification of cortical Aβ plaque-associated microglia area per plaque as a function of TREM2 genotype. c Representative images of AT8-positive NP tau pathology in the cortex and subiculum of female 5XFAD mice with differing TREM2 genotype. Quantification of d cortical and e subiculum AT8 NP tau pathology as a function of TREM2 genotype. Scale bars represent 50 µM in A and 0.4 mm in B