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Table 1 Participant characteristics stratified by endophenotype status

From: Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study

  NACC ROSMAP
Number of Participants (%) Age at Death, Mean (SD) Female, N (%) Number of Participants (%) Age at Death, Mean (SD) Female, N (%)
HS
 Overall N = 631 85.9 (8.3) 319 (50.6) N = 780 88.7 (7.2) 525 (67.3)
 No 542 (85.9) 85.9 (8.4) 270 (49.8) 707 (90.6) 88.3 (7.2) 468 (66.2)
 Yes 89 (14.1) 86.0 (7.5) 49 (55.1) 73 (9.4) 92.0 (6.4) 57 (78.1)
LATE-NC
 Overall N = 512 85.1 (7.9) 207 (50.2) N = 747 89.1 (7.1) 506 (67.7)
 No 291 (70.6) 84.9 (8.1) 138 (47.4) 499 (66.8) 87.9 (7.3) 315 (63.1)
 Yes 121 (29.4) 85.4 (7.3) 66 (57.0) 248 (33.2) 91.5 (6.1) 191 (77.0)
  1. Participant characteristics stratified by hippocampal sclerosis (HS) and limbic-predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC) case status. NACC = National Alzheimer's Coordinating Center; ROSMAP = Religious Orders Study and Rush Memory and Aging Project; SD = standard deviation; HS = hippocampal sclerosis; LATE-NC = limbic-predominant age-related TDP-43 encephalopathy neuropathological changes