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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Immune cell deconvolution of bulk DNA methylation data reveals an association with methylation class, key somatic alterations, and cell state in glial/glioneuronal tumors

Fig. 6

Immune clustering of Low-to-intermediate grade glioneuronal tumors (LIGGNT) showed distinct clusters associated with tumor type and different immune cell proportions. a UMAP clustering of eleven tumor subtypes of the LIGGNT cohort (N = 802) based on immune cell proportion (Non-cancer part scaled from 0 to 1) showed subtype specific clustering. b Two optimum number of cluster obtained in the LIGGNT cohort by using k-means clustering with Nbclust method. c Six major Immune cell type proportions shown by boxplots for each cluster indicated significant difference between immune cells distribution between two clusters. T-test and Wilcoxon test (p value shown) were used to calculate statistical significance

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