Fig. 4

Immune clustering of IDH-mut oligodendroglioma (N = 444) showed four distinct clusters associated with tumor grade and patient outcome. a UMAP clustering of OIDH tumor cohort (N = 444) based on immune cell proportion (Non-cancer part scaled from 0 to 1) showed distinct clusters. b Six major Immune cell type proportions shown by boxplots for each cluster indicated significant difference between immune cells proportion across all cluster. Y axis represents non-cancer cell proportion of particular immune cell scaled from 0 to 1. Each box plots depicted, boxes indicate interquartile range with central bar indicating median and whiskers indicating the range. Blue dot represents mean value of the proportion. T-test and Wilcoxon test (p value shown) were used to calculate statistical significance. c Tumor grade distribution of samples across all clusters. Significance based on Fisher's exact test (cluster1-cluster3; p value = 0.000017, cluster3-cluster4; p value = 0.014). d Kaplan–Meier plot showing significant difference in overall survival between cluster 1 cluster 3 and 4