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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies

Fig. 7

Biochemical fractionation followed by immunoblotting demonstrating that αSyn carboxy truncated at residue 125 is abundant in the brain of LBD patients. LBD temporal cortex adjacent to the amygdala, LBD amygdala (*), and control temporal cortex adjacent to the amygdala were biochemically fractionated as described in “Material and Methods”. 20 ug of protein from the soluble (high salt soluble) and insoluble (SDS/urea) fractions were analyzed by immunoblotting with antibody 3H11 with epitope in the middle of αSyn residues 43–62 and antibody 5C1 specific for αSyn carboxy truncated at residue 125. The relative mobilities of molecular mass protein markers are identified on the left of the blots. Arrow indicates full-length αSyn and asterisk truncated αSyn

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Acta Neuropathologica Communications

ISSN: 2051-5960

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