Fig. 7
RGS10 deficiency impacts circulating non-classical monocytes and T-cells, and colitis augments these effects. A Frequency of CD45+ cells, counts, and GMFI of CD11b for Ly-6C− MHC-II+ (non-classical) monocytes and B frequency of CD45+ cells and counts of CD4+ and CD8+ T-cells in PBMCs from mice given H2O or DSS followed by saline or MPTP determined at endpoint by flow cytometry (n = 7–10 per group (groups distinguished by sex, genotype, and treatment), two-way ANOVA, genotype effect p < 0.05 for all except female CD8+ T-cells, treatment effect p < 0.05 for male MHC-II+ monocyte frequency and male and female MHC-II+ monocyte counts, interaction p < 0.05 for male MHC-II + monocytes and male CD4 + T-cells frequency and counts, Tukey’s post hoc). Letter(s) centered above groups reflect results of post hoc tests. Groups that do not share any letter are significantly different from one another