Fig. 6
Increased tyrosine hydroxylase activity after colitis may prevent dopamine deficiency. A Ratio of TH protein phosphorylated at serine 40 to total TH measured by western blot (n = 7–9 per group (groups distinguished by sex, genotype, and treatment), two-way ANOVA, treatment effect and genotype effect p < 0.05, Tukey’s post hoc). B Levels of dopamine, C 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and D the ratio of the sum of DOPAC and HVA to dopamine measured by HPLC in striatum from mice given H2O or DSS followed by saline or MPTP (n = 6–9 per group (groups distinguished by sex, genotype, and treatment), two-way ANOVA, treatment effect p < 0.05 for all, genotype effect p < 0.05 for dopamine and HVA in females, Tukey’s post hoc). Letter(s) centered above groups reflect results of post hoc tests. Groups that do not share any letter are significantly different from one another