Fig. 5

Protein–protein interaction network among genes showing increased expression in recovery-phase relative to control microglia isolated from the cortex. The network was generated from genes differentially expressed with LFC ≥ 2 and FDR < 0.05. The number of edges in the network (n = 780) was significantly greater than expected in a random gene sample of the same order (expected n = 142, p < 10^–16). The network was enriched for proteins functioning in immune system processes (FDR = 3.68 × 10^–27), inflammatory response (FDR = 5.76 × 10^–16), chemotaxis (FDR = 1.45 × 10^–12) and cell motility (FDR = 5.67 × 10^–8), among other gene ontology annotations. The network was generated using STRING (https://string-db.org)