Skip to main content
Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates

Fig. 5

Camk2-hShh but not Pcp2-hShh normalizes locomotor hyperactivity in Ts65Dn. A Scheme for generating the forebrain-cohort (n = 14–16 per group) and the cerebellum-cohort (n = 18–21 per group) and the order of behavioral tests. All experimental animals were in B6;C3H (75%;25%) background and without Dox treatment. B Body weight of different transgenic mice at 3-month-old. C 30 min open field tests of the forebrain-cohort. Total distance traveled in 30 min (left) and distance traveled in each of 5-min-bin (right) were shown, and n = 14–16 per group. D 30 min open field tests of the cerebellum-cohort. Total distance traveled in 30 min (left) and distance traveled in each of 5-min-bin (right) were shown, and n = 18–21 per group. Data were represented as mean ± SEM. Data were analyzed by one-way ANOVA and Tukey's multiple comparisons tests (B). Total distances traveled during 30 min (the left panel of C and D) were analyzed by one-way ANOVA and Tukey's multiple comparisons tests. The distances traveled in each of 5-min-bin (the right panel of C and D) were analyzed by two-way RM ANOVA and Tukey's multiple comparisons tests. See also Additional file 11: Figure S4.

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us