Fig. 3
Correlation structure between metabolite profiles (1H-MRS) and associated transcriptome (human and mouse). The heatmap a illustrates the correlations between 13 metabolites from the last scans of the xenograft bearing mice (injected and contralateral side) and the 185 metabolite associated genes selected by SPLS and retained by the bootstrap procedure (≥ 0.1). The correlation matrix (coinertia) between genes (rows) and metabolites (columns) is ordered by the 1st axes obtained from coinertia. For each gene the species origin (human or mouse) and the frequency of selection by bootstrap are annotated on the right. b The relation between metabolite profiles and gene expression is visualized for all PDOX samples per patient on the vectorial plane defined by the coordinates on the first axes of gene expression and the metabolite profiles from the coinertia analysis, respectively. The samples from the injected side are represented by squares, and by circles for the contralateral side, the color gradient of the symbols indicates the percentage of human reads. c The metabolites projected on the first axis of the coinertia analysis. d Similarly, the correlation structure between metabolite profiles (1H-MRS) and averaged expression of the significant pathways emerging from GSEA (p ≤ 0.1) using the MSigDB is illustrated in a heatmap (d). The pathways are annotated with the adjusted p-value (p ≤ 0.1), and the proportion of human genes contributing to the pathway