Variable | Young Controls | Older Controls | PSND | PSD | VaD | AD | Mixed |
---|---|---|---|---|---|---|---|
N | 12 | 20 | 21 | 20 | 17 | 16 | 18 |
Mean Age, years (range) | 57.5* (46–65) | 79.3 (78–94) | 85.1 (75–96) | 87.1 (75–96) | 84.2 (71–98) | 84.2 (76–96) | 85.1 (72–93) |
Gender (M:F ratio) | 55:45 | 35:65 | 57:43 | 30:70 | 41:59 | 56:44 | 44:56 |
MMSE, mean ± SEM | na | 29 ± 1 | 27 ± 0.4 | 16 ± 1 | 13 ± 4 | 7 ± 2 | 11 ± 2 |
CAMCOG, mean ± SEM | na | na | 90 ± 1 | 66 ± 3 | na | 39 ± 7 | na |
Braak Stage, mean (range) | 0.25 (0–1) | 1.9 (0–4) | 2.6 (1–4) | 2.6 (1–4) | 2.0 (0–4) | 5.6 (5–6) * | 5.2 (5–6) * |
CERAD, mean (range) | 0.0 (0–0) | 0.5 (0–2) | 1.7 (1–2) | 1.3 (1–3) | 1.0 (0–2) | 2.9 (2–3) * | 2.9 (2–3) * |
ABC Scores, mean | na | A0.5, B1.2, C0.5 | A0.5, B1.2, C0.7 | A0.5, B1.2, C0.8 | A0.6, B1.2, C0.8 | A3, B3, C3 | A2.5, B2.6, C2.6 |
CAA frequency (moderate-severe), % | 0% | 6% | 15% | 18% | 17% | 39% | 9% |
Vascular pathology score, mean (range)† | na | 6.7 (0–10) * | 13.5 (13–14) | 13.3 (9–17) | 13.2 (10–16) | 10.8 (3–16) | 11.0 (6–14) |
Cortical Infarct pathology (%)†† | 0% | 0% | 90% | 90% | 67% | 41% | 73% |
WML score, mean (range)‡ | na | 0.5 (0–2) ** | 2.5 (2–3) | 2.4 (2–3) | 2.9 (2–3) | 1.8 (0–3) | 2.9 (2–3) |
WM/ Vascular lesions, moderate—severe (%)‖ | na | 17.6%** | 100% | 100% | 100% | 72% | 95% |
Length density (Lv) of Cortical GLUT1 Capillaries (mm/mm3)⁋ | na | 0.72 ± 0.10 | 0.62 ± 0.17 | 0.78 ± 0.07 | 0.72 ± 0.09 | 0.72 ± 0.13 | 0.70 ± 0.10 |