Fig. 1From: Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signalingHypothetical mechanisms of mCa2+ overload-induced cellular dysfunction in AD progression. Loss of NCLX and remodeling of the mtCU causes mCa2+ overload that leads to mPTP opening, loss of ATP, and interrupted axonal transport, resulting in AD progressionBack to article page