Spinal Muscular Atrophy autophagy profile is tissue-dependent: differential regulation between muscle and motoneurons

Table 1 Representation of autophagic markers protein level amongst different human and mouse Spinal Muscular Atrophy models

Autophagy marker	Protein level	SMA cell type and tissue	References
LC3-II	Decreased	Human: muscle, lymphocytes, fibroblasts Mouse: muscle	Present work
	Increased	Human: differentiated MNs Mouse: spinal cord, isolated MNs	Present work [17, 21, 27]
Beclin 1	Decreased	Mouse: muscle	Present work
	Increased	Mouse: spinal cord, isolated MNs	[17, 21]
p62/SQSTM1	No change	Mouse: spinal cord	[21]
	Increased	Human: differentiated MNs, fibroblasts Mouse: isolated MNs	[18,19,20]
	Decreased	Mouse: muscle	Present work
LAMP-1	No change	Mouse: muscle	Present work
	Increased	Human: fibroblasts	Present work
mTOR	No change	Human: differentiated MNs Mouse: muscle, spinal cord, isolated MNs	Present work
	Decreased	Human: fibroblasts	Present work
p-mTOR (Ser2448)	Decreased	Human: fibroblasts Mouse: muscle, spinal cord	Present work [16]
	Increased	Human: differentiated MNs Mouse: isolated MNs	Present work

ISSN: 2051-5960