Table 2 Mouse traumatic brain injury (TBI) models reporting p-Tau histopathology in the brain
Reference | Model | Impacts | ITI | EDPI | p-Tau Ab | CTE-like pathology* | ||
|---|---|---|---|---|---|---|---|---|
Repetitive TBI | Pathognomonic | Supportive | Associated | |||||
This study | WD | 5 | 24 | 7 | AT8 | P1, P2 | S1,S3,S4, S5 | A3 to A8 |
Petraglia et al. [54]** | PD | 6 | 24 | 30 | AT8 | P1, P2 | S1,S2,S3,S4 | A4, A5 |
Shin et al. [64] | WD | 20 | 24 | 42 | P(T205) | P1 | S1, S2, S4 | A5 |
Zhang et al. [78] | PD | 3 | 24 | 8 | AT8 | – | S1, S2, S5 | A1, A4, A5, A6, A7 |
Luo et al. [44] | PD | 3 | 24 | 180 | AT8 | – | S1, S2, S3 | A5 |
Briggs et al. [13] | WD | 30 | 24 | 93 | AT8 | – | S1, S5 | A1, A4, A5, A7 |
Albayram et al. [1]** | RIA | 7 | 24 | 14 | Cisptau | – | S1, S5 | A1, A4,A5, A7 |
Selvaraj et al. [62] | PD | 3 | 24 | 8 | P(S404) | – | S1, S2 | A1, A4, A5, A6 |
Kondo et al. [40]** | RIA | 7 | 24 | 10 | Cisptau | – | S1, S2 | A6, A7 |
Albayram et al. [2] | RIA | 5 | 24 | 240 | AT8 | – | S1, S2 | A4 |
Yang et al. [76] | PD | 4 | 72 | 10 | CP13 | – | S1, S2 | A5 |
Sacramento et al. [58] | PD | 10 | 2 | 21 | AT8 | – | S1,S2 | – |
Tagge et al. [69] | RIA | 2 | 0.25 | 1 | Cisptau | – | S1 | A4, A5, A7, A8 |
Rehman et al. [56] | WD | 3 | 24 | 7 | P(S413) | – | S1 | A1, A6, A8 |
Seo et al. [63] | WD | 3 | 72 | 7 | PHF | – | S2 | – |
Niziolek et al. [51] | WD | 4 | 48 | 30 | P(S262) | – | S2 | – |
Single TBI | ||||||||
Liu et al. [42] | RIA | 1 | n/a | 30 | T231 | P1 | S1, S2 | – |
Petraglia et al. [54]** | PD | 1 | n/a | 30 | AT8 | – | S1, S2, S3 | A5 |
Goldstein et al. [26] | PD | 1 | n/a | 14 | CP13 | – | S1,S2 | A4, A5, A6, A7 |
Kondo et al. [40]** | RIA | 1 | n/a | 1 | Cisptau | – | S1, S2 | A6, A7 |
Huber et al. [35] | Blast | 1 | n/a | 30 | CP13 | – | S1,S2 | A6 |
Sabbagh et al. [57] | Blast | 1 | n/a | 56 | T231 | – | S1, S2 | – |
Iliff et al. [37] | PD | 1 | n/a | 28 | AT8 | – | S1 | A4, A5, A7 |
Albayram et al. [1]** | RIA | 1 | n/a | 14 | Cisptau | – | S1 | A1, A7 |
Logsdon et al. [43] | Blast | 1 | n/a | 3 | T22 | – | S1 | A5,A8 |
Niziolek et al. [50] | WD | 1 | n/a | 30 | P(S262) | – | S2 | A4 |