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Table 2 Mouse traumatic brain injury (TBI) models reporting p-Tau histopathology in the brain

From: Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature

Reference Model Impacts ITI EDPI p-Tau Ab CTE-like pathology*
Repetitive TBI Pathognomonic Supportive Associated
This study WD 5 24 7 AT8 P1, P2 S1,S3,S4, S5 A3 to A8
Petraglia et al. [54]** PD 6 24 30 AT8 P1, P2 S1,S2,S3,S4 A4, A5
Shin et al. [64] WD 20 24 42 P(T205) P1 S1, S2, S4 A5
Zhang et al. [78] PD 3 24 8 AT8 S1, S2, S5 A1, A4, A5, A6, A7
Luo et al. [44] PD 3 24 180 AT8 S1, S2, S3 A5
Briggs et al. [13] WD 30 24 93 AT8 S1, S5 A1, A4, A5, A7
Albayram et al. [1]** RIA 7 24 14 Cisptau S1, S5 A1, A4,A5, A7
Selvaraj et al. [62] PD 3 24 8 P(S404) S1, S2 A1, A4, A5, A6
Kondo et al. [40]** RIA 7 24 10 Cisptau S1, S2 A6, A7
Albayram et al. [2] RIA 5 24 240 AT8 S1, S2 A4
Yang et al. [76] PD 4 72 10 CP13 S1, S2 A5
Sacramento et al. [58] PD 10 2 21 AT8 S1,S2
Tagge et al. [69] RIA 2 0.25 1 Cisptau S1 A4, A5, A7, A8
Rehman et al. [56] WD 3 24 7 P(S413) S1 A1, A6, A8
Seo et al. [63] WD 3 72 7 PHF S2
Niziolek et al. [51] WD 4 48 30 P(S262) S2
Single TBI
Liu et al. [42] RIA 1 n/a 30 T231 P1 S1, S2
Petraglia et al. [54]** PD 1 n/a 30 AT8 S1, S2, S3 A5
Goldstein et al. [26] PD 1 n/a 14 CP13 S1,S2 A4, A5, A6, A7
Kondo et al. [40]** RIA 1 n/a 1 Cisptau S1, S2 A6, A7
Huber et al. [35] Blast 1 n/a 30 CP13 S1,S2 A6
Sabbagh et al. [57] Blast 1 n/a 56 T231 S1, S2
Iliff et al. [37] PD 1 n/a 28 AT8 S1 A4, A5, A7
Albayram et al. [1]** RIA 1 n/a 14 Cisptau S1 A1, A7
Logsdon et al. [43] Blast 1 n/a 3 T22 S1 A5,A8
Niziolek et al. [50] WD 1 n/a 30 P(S262) S2 A4
  1. *See Table 1 for definitions. **Used both single and repetitive TBI. EDPI indicates the earliest day post injury at which p-Tau was found after TBI. If more than one p-Tau Ab was used only the antibody used to depict the main results is indicated. ITI, inter-injury-interval (hours), n/a, not applicable; PD, piston driven; RIA, rotational impact acceleration; WD, weight drop. Four studies reporting p-Tau exclusively in the optic tract and cerebellum are excluded from this table. P, S, and A refer to pathognomonic, supportive, and associated pathology (see Table 1 for details). Dashes indicate histopathological feature not reported or not found. Studies not showing p-Tau in the cerebral cortex or hippocampus are omitted from this table