Fig. 7
From: RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein
SIRT6 mediates the oncogenic activity of RBM5-AS1 in medulloblastoma. A Western blot analysis showed depletion of SIRT6 in medulloblastoma cells. B Effect of SIRT6 knockdown on self-renewal capacity of cancer stem cells. C Depletion of SIRT6 enhanced radiation-induced DNA damage. D Western blot analysis confirmed overexpression of SIRT6 in medulloblastoma cells. E Overexpression of SIRT6 rescued RBM5-AS1 depletion-induced radiosensitization. F Overexpression of SIRT6 attenuated RBM5-AS1 depletion-induced DNA damage response. *P < 0.05