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Table 1 Enzymes involved in adenosine homeostasis

From: Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy

Gene WTC WTJ TauC TauJ
ADA 1.06 ± 0.09 1.04 ± 0.06 3.47 ± 0.42* 1.35 ± 0.24#
ADK 1.02 ± 0.03 1.06 ± 0.02 1.17 ± 0.06 0.85 ± 0.09#
CD39 1.01 ± 0.03 1.23 ± 0.02* 1.45 ± 0.06* 0.94 ± 0.05#
CD73 1.02 ± 0.04 1.23 ± 0.07* 1.33 ± 0.05* 1.13 ± 0.05#
  1. Mice were treated as indicated (control WT mice, WTC; J4-treated WT mice, WTJ; control Tau22 mice, TauC; and J4-treated Tau22 mice, TauJ; n = 6–9 in each group) from the age of 3–11 months. The hippocampus was harvested carefully and subjected to RT-qPCR. GAPDH was used as a reference gene for normalization. The data are expressed as the mean ± SEM. *p < 0.05 versus the WT vehicle group; #p < 0.05 versus the Tau22 vehicle group