Fig. 3

α-dystroglycan expression in the frontal WM of non-neurological controls and leukodystrophy patients. α-dystroglycan in controls is expressed at the vasculature, where it stains in between basement membrane and astrocyte endfeet. Its expression is reduced in blood vessels with reduced UEA I expression, including AxD, ALSP, X-ALD and AGS. Astrocytes are stained with GFAP, endothelial cells with UEA I and nuclei with DAPI. Scale bar = 25 µm