Fig. 2
From: Pathology of the neurovascular unit in leukodystrophies
ZO-1 expression in the frontal WM non-neurological controls and leukodystrophy patients. ZO-1 is expressed in between the endothelial cells (UEA I) of non-neurological controls. The expression pattern of ZO-1 in PMD, MLD and ALSP is as that observed in controls. By contrast, in AxD (infantile- and adolescent-onset), AGS, LARS-2-related leukodystrophy, CARASAL and X-ALD, the expression of ZO-1 is also observed outside the vasculature, where it shows a vesicular pattern in the extracellular matrix. Astrocytes are stained with GFAP (green) and nuclei with DAPI. Scale bar = 25 µm