Table 1 Distribution of neuronal loss and pTDP-43- and annexin A11-immunoreactive NCIs and GCIs
Neuronal loss | pTDP-43 | Annexin A11 | |||
|---|---|---|---|---|---|
NCIs | GCIs | NCIs | GCIs | ||
Cerebrum | |||||
Frontal cortex | − | − | − | − | − |
Motor cortex | ++ | ++ | ++ | + | − |
White matter* | +** | NA | ++ | NA | − |
Temporal cortex | − | − | − | − | − |
Parietal cortex | − |  +  | − | − | − |
Occipital cortex | − | − | − | − | − |
Subcortical area | |||||
Ammon/dentate gyrus | − | − | − | − | − |
Amygdaloid nucleus | − | − | − | − | − |
Caudate nucleus/putamen | −/− | +/+ | −/+ | −/+ | −/+ |
Globus pallidus | − | − | − | − | − |
Thalamus | − | − | − | − | − |
Subthalamic nucleus | − | + | + | − | − |
Brainstem | |||||
Oculomotor nucleus | − | − | + | − | − |
Substantia nigra | − | − | − | − | − |
Locus ceruleus | − | + | − | − | − |
Trigeminal motor nucleus | + | + | − | + | − |
Facial nucleus | ++ | ++ | + | ++ | − |
Pontine nucleus | − | + | + |  +  | − |
Ambiguous nucleus | + | + | − | − | − |
Hypoglossal nucleus | ++ | ++ | ++ | ++ | − |
Inferior olivary nucleus | − | + | + | + | − |
Reticular formation | − | + | + | + | − |
Cerebellum | |||||
Cortex/white matter | −/−** | −/NA | −/+ | −/NA | −/− |
Dentate nucleus | − | − | − | − | − |
Spinal cord | |||||
Anterior horn (C/Th/L) | ++/++/+ | +/+/++ | ++/++/++ | +/+/++ | −/−/+ |
Lateral funiculus (C/Th/L) | ++/++/+** | NA | −/+/+ | NA | −/−/− |
Anterior funiculus (C/Th/L) | ++/++/−** | NA | +/+/+ | NA | −/−/− |