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Table 1 Distribution of neuronal loss and pTDP-43- and annexin A11-immunoreactive NCIs and GCIs

From: A novel splicing variant of ANXA11 in a patient with amyotrophic lateral sclerosis: histologic and biochemical features

  Neuronal loss pTDP-43 Annexin A11
NCIs GCIs NCIs GCIs
Cerebrum
Frontal cortex
Motor cortex ++ ++ ++ +
White matter* +** NA ++ NA
Temporal cortex
Parietal cortex  + 
Occipital cortex
Subcortical area
Ammon/dentate gyrus
Amygdaloid nucleus
Caudate nucleus/putamen −/− +/+ −/+ −/+ −/+
Globus pallidus
Thalamus
Subthalamic nucleus + +
Brainstem
Oculomotor nucleus +
Substantia nigra
Locus ceruleus +
Trigeminal motor nucleus + + +
Facial nucleus ++ ++ + ++
Pontine nucleus + +  + 
Ambiguous nucleus + +
Hypoglossal nucleus ++ ++ ++ ++
Inferior olivary nucleus + + +
Reticular formation + + +
Cerebellum
Cortex/white matter −/−** −/NA −/+ −/NA −/−
Dentate nucleus
Spinal cord
Anterior horn (C/Th/L) ++/++/+ +/+/++ ++/++/++ +/+/++ −/−/+
Lateral funiculus (C/Th/L) ++/++/+** NA −/+/+ NA −/−/−
Anterior funiculus (C/Th/L) ++/++/−** NA +/+/+ NA −/−/−
  1. *, White matter adjacent to the motor cortex; Neuronal loss (**, degeneration with macrophage infiltration): −, none; +, mild to moderate; ++, severe; NCIs and GCIs: −, none; +, rare (1–4 /10 high-power fields); ++, occasional ( 5/10 high-power fields); pTDP-43, phosphorylated 43 kDa TAR DNA-binding protein; NCIs, neuronal cytoplasmic inclusions; GCIs, glial cytoplasmic inclusions; NA, not applicable; C, cervical cord; Th, thoracic cord; L, lumbar cord