Fig. 5

Sarm1 knockout improves motor learning in chronic stage TBI. Miss-step wheels have irregularly spaced rungs to assess motor skill learning (week 1) followed by a plateau phase (week 2) that tests bilateral sensorimotor function. a Sarm1 KO mice more quickly learn to run at a faster average velocity compared to Sarm1 WT mice, but this improvement does not reach statistical significance (p = 0.0821). b Sarm1 KO mice run on the wheels more frequently than Sarm1 WT during the learning phase. c Running behavior accumulates to increased total distance traveled during the learning phase in Sarm1 KO mice compared to Sarm1 WT mice. There were no statistically significant differences between genotypes in the three measures during the plateau phase (a–c). Sarm1 WT: n = 9 TBI. Sarm1 KO: n = 15 TBI. ns = not significant. Further statistical details are provided in Additional File 1: Table S4