Fig. 6
From: The degree of astrocyte activation is predictive of the incubation time to prion disease
Correlations between GSA scores for individual gene sets and incubation time to disease. (a) Hierarchical clustering of grouped data for cortex (n = 6 for normal females, n = 3 for other groups). Astrocyte state reporters (left panel) include A1-, A2-, pan-specific markers, other markers of reactive astrocytes, regulators of astrocyte reactivity, transcription factors, growth factors, and receptors. Astrocyte function genes (middle panel) include BBB, channels, lipid/cholesterol homeostasis, myelination, energy metabolism, extracellular matrix, gliotransmitters, transporters, and glutamate-glutamine cycle genes. Genes related to the astrocyte function in neuroprotection/synaptogenesis, and neurotoxicity/synapse elimination are presented on the right panel. (b) Simple linear regressions built for GSA scores of selected gene sets and incubation time to disease showing a strong inverse correlation. Cortex samples from i.c. female and male groups were used