Skip to main content

Table 4 Summary of data from seeding WT-SOD1:YFP and GurWT-SOD1 mice

From: Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

Host Inoculum (ISP) # inoculated # paralysis Age of euthanasia due to age
WT-SOD1:YFP PBS 3 0 17—20 mo (a)
WT-SOD1:YFP NTg Sp Cord 4 0 20 mo (b)
WT-SOD1:YFP GurWT Sp Cord 15 0 19–20 mo (b)
WT-SOD1:YFP recWT fibrils 10 0 16–20 mo (d)
GurWT PBS 3 0 20 mo (e)
GurWT NTg Sp Cord 3 0 20 mo (f)
GurWT GurWT Sp Cord 6 0 19 mo
GurWT recWT SOD1 fibrils 7 0 16–20 mo
GurWT GurG93A Sp Cord 4 0 17–20 mo
GurWT L126Z Sp Cord 3 0 18–19 mo (g)
GurWT QV103Z Sp Cord 3 1 19–20 mo (h)
  1. (a) Data originally reported in [15]
  2. (b) 1 found dead @ 7 mo. Data originally reported in [15]
  3. (c) 1 found dead @ 4.3 mo, 2 euthanized for non ALS-related issues at 8.7 and 15 mo. Includes data for 5 animals originally reported in [15]
  4. (d) 1 found dead @ 5.4 mo, 2 euthanized for non-ALS-related issues at 7 and 18 mo
  5. (e) 3 found dead @ 4.5 -5.4 mo, 1 euthanized at 3 mo
  6. (f) Data originally reported in [15]
  7. (g) 1 found dead at 18.8 mo – no prior clinical signs
  8. (h) 1 animal showed bilateral weakness at 20 months when euthanized but lacked inclusion pathology