Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

Table 4 Summary of data from seeding WT-SOD1:YFP and GurWT-SOD1 mice

Host	Inoculum (ISP)	# inoculated	# paralysis	Age of euthanasia due to age
WT-SOD1:YFP	PBS	3	0	17—20 mo (a)
WT-SOD1:YFP	NTg Sp Cord	4	0	20 mo (b)
WT-SOD1:YFP	GurWT Sp Cord	15	0	19–20 mo (b)
WT-SOD1:YFP	recWT fibrils	10	0	16–20 mo (d)
GurWT	PBS	3	0	20 mo (e)
GurWT	NTg Sp Cord	3	0	20 mo (f)
GurWT	GurWT Sp Cord	6	0	19 mo
GurWT	recWT SOD1 fibrils	7	0	16–20 mo
GurWT	GurG93A Sp Cord	4	0	17–20 mo
GurWT	L126Z Sp Cord	3	0	18–19 mo (g)
GurWT	QV103Z Sp Cord	3	1	19–20 mo (h)

(a) Data originally reported in [15]
(b) 1 found dead @ 7 mo. Data originally reported in [15]
(c) 1 found dead @ 4.3 mo, 2 euthanized for non ALS-related issues at 8.7 and 15 mo. Includes data for 5 animals originally reported in [15]
(d) 1 found dead @ 5.4 mo, 2 euthanized for non-ALS-related issues at 7 and 18 mo
(e) 3 found dead @ 4.5 -5.4 mo, 1 euthanized at 3 mo
(f) Data originally reported in [15]
(g) 1 found dead at 18.8 mo – no prior clinical signs
(h) 1 animal showed bilateral weakness at 20 months when euthanized but lacked inclusion pathology

ISSN: 2051-5960