Combined epigenetic/genetic study identified an ALS age of onset modifier

Table 2 The association of rs4970944 and its tagging variants with ALS age of onset in the discovery and replication cohorts

SNP	Location (hg19)	MAF	Discovery stage (n = 469)			Replication stage (n = 4160)
			B	SE	P value	B	SE	P value
rs4970944	chr1:151,163,317	0.32	2	0.9	0.025	0.8	0.3	0.007
rs10888406	chr1:151,166,896	0.32	2	0.9	0.025	0.8	0.3	0.007
rs11204785	chr1:151,150,857	0.33	NA	NA	NA	0.7	0.3	0.013
rs11807075	chr1:151,153,806	0.33	NA	NA	NA	0.7	0.3	0.014

Results from the additive multivariate linear regression model are presented (adjusted for sex, ALS site of onset and family history). Non-Finnish European minor allele frequencies (MAF) were extracted from the gnomAD database (NA = not available, B = linear regression coefficient Beta, SE = standard error)

ISSN: 2051-5960