Fig. 2
From: Sex-specific DNA methylation differences in Alzheimer’s disease pathology
An overview of the sex-stratified analysis and sex-by-Braak stage interaction analysis. For each CpG, we performed two complementary analytical strategies, a sex-stratified analysis that examined methylation-Braak stage associations in male and female samples separately, and a sex-by-Braak stage interaction analysis that compared the magnitude of these associations between different sexes. At 5% FDR, the sex-stratified analysis identified 381 CpGs in the analysis of female samples and 76 CpGs in analysis of male samples, which were enriched in different biological pathways and genomic features