Table 1 Characteristics of subjects by diabetes status
From: Brain insulin signaling and cerebrovascular disease in human postmortem brain
| Â | Total | Diabetes | No Diabetes |
|---|---|---|---|
n = 150 | n = 75 | n = 75 | |
Demographic | |||
 Age-at-death in years, mean (SD) | 86.6 (6.1) | 86.6 (5.9) | 86.7 (6.3) |
 Women, n (%) | 72 (48%) | 36 (48%) | 36 (48%) |
 Education in years, mean (SD) | 18.1 (3.3) | 18.2 (3.1) | 18.1 (3.4) |
 APOE ε4, n (%) | 36 (24%) | 15 (20%) | 21 (28%) |
Neuropathologic | |||
Brain infarcts (presence), n (%) | |||
 Any type infarct (by size and location) | |||
  One infarct | 29 (19%) | 13 (17%) | 16 (21%) |
  More than one infarct | 46 (31%) | 32 (43%) | 14 (19%) |
 Gross infarcts | |||
  One infarct | 28 (19%) | 14 (19%) | 14 (19%) |
  More than one infarct | 28 (19%) | 19 (25%) | 9 (12%) |
 Microinfarcts | |||
  One infarct | 26 (17%) | 16 (21%) | 10 (13%) |
  More than one infarct | 19 (14%) | 12 (16%) | 7 (9%) |
 Cortical infarcts | |||
  One infarct | 20 (13%) | 12 (16%) | 8 (11%) |
  More than one infarct | 15 (11%) | 9 (12%) | 6 (8%) |
 Subcortical infarcts | |||
  One infarct | 28 (19%) | 16 (21%) | 12 (16%) |
  More than one infarct | 30 (20%) | 22 (29%) | 8 (11%) |
Cerebral vessel pathologies | |||
 Atherosclerosis | |||
  Mild | 71 (47%) | 31 (41%) | 40 (53%) |
  Moderate | 49 (33%) | 25 (33%) | 24 (32%) |
  Severe | 12 (8%) | 8 (11%) | 4 (5%) |
 Arteriolosclerosis | |||
  Mild | 44 (30%) | 25 (33%) | 19 (25%) |
  Moderate | 31 (21%) | 12 (16%) | 19 (25%) |
  Severe | 15 (10%) | 12 (16%) | 3 (4%) |
 Cerebral amyloid angiopathy | |||
  Mild | 39 (27%) | 31 (41%) | 29 (39%) |
  Moderate | 31 (21%) | 14 (19%) | 17 (23%) |
  Severe | 15 (10%) | 6 (8%) | 9 (12%) |
Alzheimer’s disease pathology | |||
 Global score | 0.6 (0.6) | 0.7 (0.6) | 0.6 (0.5) |